{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:26:56Z","timestamp":1777667216869,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p>1 The plasma elimination half-life of dextropropoxyphene and its metabolite nordextropropoxyphene was investigated in seven elderly hospital patients after the administration of both single and multiple doses of Distalgesic.<\/jats:p>\n                  <jats:p>2 The mean elimination half-life of dextropropoxyphene after multiple dosing was 35.7 h (range 24.0-50.6 h) and the mean half-life of nordextropropoxyphene was 53.3 h (range 25.1-76.3 h).<\/jats:p>\n                  <jats:p>3 The half-lives of both dextropropoxyphene and nordextropropoxyphene are much longer than those reported by other investigators in younger subjects.<\/jats:p>","DOI":"10.1177\/096032718400300105","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T20:31:00Z","timestamp":1236198660000},"page":"41s-48S","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacokinetics of Dextropropoxyphene and Nordextropropoxyphene in Elderly Hospital Patients after Single and Multiple Doses of Distalgesic. Preliminary Analysis of Results"],"prefix":"10.1177","volume":"3","author":[{"given":"P.","family":"Crome","sequence":"first","affiliation":[{"name":"George Stamp Unit, Orpington Hospital, Orpington, Kent\rBR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gain","sequence":"additional","affiliation":[{"name":"George Stamp Unit, Orpington Hospital, Orpington, Kent\rBR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ghurye","sequence":"additional","affiliation":[{"name":"George Stamp Unit, Orpington Hospital, Orpington, Kent\rBR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"George Stamp Unit, Orpington Hospital, Orpington, Kent\rBR6 9JU, Poisons Unit, Guy's Hospital, London SE1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/dtb.21.1.1","volume":"21","year":"1983","journal-title":"Drug Ther. Bull."},{"key":"atypb2","unstructured":"Crome, P. (1982). Drug compliance in the elderly. In Psychopharmacology of Old Age, pp. 55-64. Oxford: Oxford University Press."},{"key":"atypb3","first-page":"418","volume":"7","year":"1979","journal-title":"Br. J. Clin. Pharmacol."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1979264473"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.0954-6820.1978.tb14841.x","volume":"203","year":"1978","journal-title":"Acta Med. Scand."}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:48Z","timestamp":1777448748000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718400300105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":5,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1177\/096032718400300105"],"URL":"https:\/\/doi.org\/10.1177\/096032718400300105","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}