{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:27:00Z","timestamp":1777667220335,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p>1 The number of deaths from acute poisoning in England and Wales has remained constant at approximately 4000 per annum for the last 10 years despite major changes in the agents responsible. Deaths due to carbon monoxide and barbiturate and non-barbiturate hypnotics have fallen, while those due to psychotropic and analgesic drugs have risen.<\/jats:p>\n                  <jats:p>2 The number of hospital admissions in England and Wales due to analgesics taken in overdose has risen from 15 940 in 1968 to 24 930 in 1980, with aspirin and paracetamol being the preparations most commonly ingested. Currently, the mortality from salicylate intoxication is falling while that due to paracetamol is rising. In 1980, the Office of Population Censuses and Surveys recorded 790 deaths from analgesic poisoning, of which 181 were due to salicylates and 152 to paracetamol alone. A further 269 deaths were attributed to paracetamol and dextropropoxyphene, and an additional 132 deaths were thought to be due to paracetamol in combination with other drugs.<\/jats:p>\n                  <jats:p>3 An important factor in the changing mortality from salicylate and paracetamol poisoning is the trend observed in the sales and usage of these agents. Since 1979, the number of analgesic tablets containing aspirin sold in the UK (except Northern Ireland), excluding hospital use, has fallen by 326 x 106, while sales of those containing paracetamol have increased by 395 \u00d7 106 tablets.<\/jats:p>","DOI":"10.1177\/096032718400300108","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T20:31:00Z","timestamp":1236198660000},"page":"61s-74S","source":"Crossref","is-referenced-by-count":13,"title":["Epidemiology of Analgesic Overdose in England and Wales"],"prefix":"10.1177","volume":"3","author":[{"given":"T.J.","family":"Meredith","sequence":"first","affiliation":[{"name":"Guy's Hospital, London Bridge, London SE 19RT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Vale","sequence":"additional","affiliation":[{"name":"West Midlands Poisons Unit, Dudley Road Hospital, Birmingham\rB 18 7QH, UK, Royal College of Physicians of London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,1,1]]},"reference":[{"key":"atypb1","volume-title":"British Pharmaceutical Index","year":"1979"},{"key":"atypb2","first-page":"501","year":"1974","journal-title":"Br. Med. J."},{"key":"atypb3","unstructured":"Hospital In-Patient Enquiry (1968-1980). Main Tables Series MB4. Department of Health and Social Security, Office of Population Censuses and Surveys, Welsh Office (Table 5, 1968-1978, ICD Codes N960-N989; Table 14,1979-1980, ICD Codes 960-989)."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/096032718300200218"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/002580248302300307"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/096032718100100102"},{"key":"atypb7","volume-title":"Mortality Statistics - Cause, Series DH2 (Table 2, 1974-1978, ICD Codes N960-N989; Table 2,1979-1982, ICD Codes 960-989)","year":"1974"},{"key":"atypb8","volume-title":"Mortality Statistics - Accidents and Violence, Series DH4 (Tables 9 and 10)","year":"1974"},{"key":"atypb9","volume-title":"Mortality Statistics (Table 7, 1968-1973, ICD Codes N960-N989)","year":"1968"},{"key":"atypb10","doi-asserted-by":"crossref","unstructured":"Vale, J.A. & Meredith, T.J. (1981). Epidemiology of poisoning in the UK. In Poisoning: Diagnosis and Treatment, eds J. A. Vale & T. J. Meredith , pp. 1-8. Lancaster: MTP Press.","DOI":"10.1007\/978-94-011-6763-5_1"}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:49Z","timestamp":1777448749000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718400300108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":10,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1177\/096032718400300108"],"URL":"https:\/\/doi.org\/10.1177\/096032718400300108","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}