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The resultant deficiency of this cation causes an increase in intramyocardial cytosolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and aggravates the decrease in intramyocardial K\n                    <jats:sup>+<\/jats:sup>\n                    provoked by diuretics through their hyperkaliuretic effect. Thus the myocardium is electrically destabilized and cardiac arrhythmias may develop. Mg\n                    <jats:sup>2+<\/jats:sup>\n                    deficiency positively contributes to the development of atherogenic alterations in lipid metabolism, vasospastic phenomena in the coronary and cerebrovascular territories, myocardial infarction and to the retardation of infarct healing and the occurrence of ventricular arrhythmias during the acute phase of infarction.\n                  <\/jats:p>","DOI":"10.1177\/096032718400300501","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"351-371","source":"Crossref","is-referenced-by-count":19,"title":["Cardiovascular Toxicity of Diuretics Related to Magnesium Depletion"],"prefix":"10.1177","volume":"3","author":[{"given":"A.J.","family":"Reyes","sequence":"first","affiliation":[{"name":"Departamento de Investigaci\u00f3n Cardiovascular, Fundaci\u00f3n Procardias, and Universidad de la Rep\u00fablica, Montevideo, Uruguay, Department of Experimental and Clinical Pharmacology, University of Natal, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.P.","family":"Leary","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n Cardiovascular, Fundaci\u00f3n Procardias, and Universidad de la Rep\u00fablica, Montevideo, Uruguay, Department of Experimental and Clinical Pharmacology, University of Natal, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"atypb1","first-page":"77","volume":"11","author":"Altura, B.M.","year":"1982","journal-title":"Adv. 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