{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:53:11Z","timestamp":1789890791006,"version":"4.0.1"},"reference-count":8,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:p>1 Clinical details of seven patients who suffered adverse reactions to N-acetylcysteine as Parvolex are documented.<\/jats:p>\n                  <jats:p>2 Skin testing was carried out to diluted Parvolex, and its individual components N-acetylcysteine and ethylenediaminetetra-acetate, in five reacting patients and five patients who had received Parvolex with no ill-effects.<\/jats:p>\n                  <jats:p>3 Weal responses to high concentrations (20 mg\/ml) of acetylcysteine as Parvolex were significantly greater ( p &lt; 0.02) in reactors. There were no other significant differences between the groups.<\/jats:p>\n                  <jats:p>4 In two patients who reacted, the effects of intradermal Parvolex could be inhibited by prior therapy with the antihistamine terfenadine.<\/jats:p>\n                  <jats:p>5 These results suggest a 'pseudo-allergic' rather than an immunological aetiology for adverse reactions to Parvolex.<\/jats:p>","DOI":"10.1177\/096032718400300504","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"393-398","source":"Crossref","is-referenced-by-count":57,"title":["Adverse Reactions to N-Acetylcysteine"],"prefix":"10.1177","volume":"3","author":[{"given":"D.N.","family":"Bateman","sequence":"first","affiliation":[{"name":"Department of Medicine, Freeman Hospital, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.W.","family":"Woodhouse","sequence":"additional","affiliation":[{"name":"Department of Medicine, Freeman Hospital, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Rawlins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Freeman Hospital, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb07907.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6396.876"},{"key":"atypb3","unstructured":"Kallos, P. & West, G.B. (1983). Pseudo-allergic reactions in man. In Recent Advances in Clinical Pharmacology 3, eds P. Turner & D.G. Shand, pp. 235-252. London: Churchill-Livingstone."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90612-2"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6198.1097"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6400.1223"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90188-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92306-7"}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:00Z","timestamp":1777448760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718400300504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1177\/096032718400300504"],"URL":"https:\/\/doi.org\/10.1177\/096032718400300504","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}