{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T17:57:41Z","timestamp":1781373461825,"version":"3.54.1"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1984,11,1]],"date-time":"1984-11-01T00:00:00Z","timestamp":468115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:p>1 Plasma levels of levomepromazine and two of its major metabolites N-desmethyl-levomepromazine and levomepromazine sulphoxide were studied in two poisoned patients treated with resin haemoperfusion at a constant blood flow of 200 ml\/min.<\/jats:p>\n                  <jats:p>2 The mean haemoperfusion clearance of levomepromazine, N-desmethyl-levomepromazine and levomepromazine sulphoxide was 114, 123 and 151 ml\/min, respectively, in patient no. 1, and 153, 148 and 184 ml\/min, respectively, in patient no. 2. Patient no. 2 had also ingested amitriptyline, and the mean haemoperfusion clearance of amitriptyline and its metabolite nortriptyline was 183 and 183 ml\/min respectively.<\/jats:p>\n                  <jats:p>3 Haemoperfusion did not seem to alter the elimination profile of levomepromazine or the two metabolites in either patient.<\/jats:p>\n                  <jats:p>4 We conclude that haemoperfusion is of little value in removing levomepromazine, N-desmethyl-levomepromazine or levomepromazine sulphoxide from the body. This is probably due to the large apparent volume of distribution and the high intrinsic hepatic metabolic clearance of these compounds.<\/jats:p>","DOI":"10.1177\/096032718400300604","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"497-503","source":"Crossref","is-referenced-by-count":6,"title":["Resin Haemoperfusion in Levomepromazine Poisoning: Evaluation of Effect on Plasma Drug and Metabolite Levels"],"prefix":"10.1177","volume":"3","author":[{"given":"P.-A.","family":"Hals","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Medical Biology, University of Troms\u00f8, PO Box 977, N-9001 Troms\u00f8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Medical Department 7 and Division of Clinical Pharmacology and Toxicology, The Central Laboratory, Ullev\u00c5l University Hospital, N-0407 Oslo 4, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1984,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)81680-5"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1976194435"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198204000-00012"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00607681"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1982.tb00956.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/096032718200100401"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00546717"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6033.472-c"}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718400300604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:02Z","timestamp":1777448762000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718400300604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1177\/096032718400300604"],"URL":"https:\/\/doi.org\/10.1177\/096032718400300604","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}