{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:23:29Z","timestamp":1780539809094,"version":"3.54.1"},"reference-count":7,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1984,11,1]],"date-time":"1984-11-01T00:00:00Z","timestamp":468115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:p>1 A 58-year-old man with a history of alcoholic liver disease and chronic airflow obstruction presented with heart failure and acute bronchitis.<\/jats:p>\n                  <jats:p>2 Plasma methylxanthines were estimated as a guide to further theophylline therapy and serious caffeine accumulation was noted in the presence of a subtherapeutic concentration of theophylline.<\/jats:p>\n                  <jats:p>3 After 3 weeks on a caffeine-free diet theophylline and caffeine challenge tests were performed which demonstrated the ease with which caffeine could accumulate.<\/jats:p>\n                  <jats:p>4 The importance of caffeine accumulation during theophylline therapy is discussed.<\/jats:p>","DOI":"10.1177\/096032718400300606","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"509-512","source":"Crossref","is-referenced-by-count":11,"title":["Unsuspected Caffeine Toxicity Complicating Theophylline Therapy"],"prefix":"10.1177","volume":"3","author":[{"given":"S.A.","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, University College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, University College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.B.","family":"Leakey","sequence":"additional","affiliation":[{"name":"Academic Department of Child Health, Queen Elizabeth Hospital for Children, Hackney Road, Bethnal Green, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rydlewski","sequence":"additional","affiliation":[{"name":"Academic Department of Child Health, Queen Elizabeth Hospital for Children, Hackney Road, Bethnal Green, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Pharmacology, University College Hospital, Gower Street, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gertner","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Pharmacology, University College Hospital, Gower Street, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1984,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80246-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197706302962603"},{"key":"atypb3","unstructured":"Rall, T.W. (1980). The xanthines. In Pharmacological Basis of Therapeutics , 6th edn, eds A. Goodman Gilman, L. S. Goodman & A. Gilman, pp. 592-607. New York: Macmillan."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/ajcp\/73.3.390","volume":"73","author":"Statland, B.E.","year":"1980","journal-title":"Am. J. Clin. Pathol."},{"key":"atypb5","first-page":"371","volume":"34","author":"Tang-Liu, D.D.","year":"1981","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"issue":"1","key":"atypb6","first-page":"4","volume":"7","author":"Trembath, P.W.","year":"1979","journal-title":"J. Int. Med. 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