{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:49:11Z","timestamp":1777668551698,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>\n                    Hydrogen cyanide was administered intravenously at doses of 0.67 or 1.34 mg kg\n                    <jats:sup>-1<\/jats:sup>\n                    to beagle pitches after protection with oral p-aminopropiophenone (0.5 mg kg\n                    <jats:sup>-1<\/jats:sup>\n                    ). Hydrogen cyanide was also administered to unprotected bitches at the lower level (0.67 mg kg\n                    <jats:sup>-1<\/jats:sup>\n                    ) only. PAPP protection caused sequestration of cyanide inside the red cells. In the case of the lower dose of cyanide this resulted in a lower plasma cyanide in protected than unprotected bitches. In the case of the higher dose it resulted in survival, despite 1.34 mg kg\n                    <jats:sup>-1<\/jats:sup>\n                    being a known lethal dose. It is concluded that prior administration of PAPP ameliorated the effects of cyanide poisoning.\n                  <\/jats:p>","DOI":"10.1177\/096032718700600206","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T18:53:20Z","timestamp":1238612000000},"page":"139-145","source":"Crossref","is-referenced-by-count":11,"title":["Effect on Blood and Plasma Cyanide Levels and on Methaemoglobin Levels of Cyanide         Administered with and without Previous Protection using PAPP"],"prefix":"10.1177","volume":"6","author":[{"given":"T.C.","family":"Marrs","sequence":"first","affiliation":[{"name":"Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire, SP4 0JQ,           UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Bright","sequence":"additional","affiliation":[{"name":"Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire, SP4 0JQ,           UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"atypb1","author":"McNamara BP","year":"1976","journal-title":"Arsenal Technical Report No."},{"key":"atypb2","first-page":"744","volume":"3","author":"Rtecs","year":"1981","journal-title":"Clinical and Experimental Toxicology of Cyanides"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(52)90256-7"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)91914-6"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.24.040184.002315"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.1.132"},{"key":"atypb7","author":"Drawbaugh R.","journal-title":"Comparative Biochemistry and Physiology; in press."},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.3109\/15563657908992451"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3109\/15563657908992450"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293652"},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00348856","volume":"51","author":"Marrs TC","year":"1982","journal-title":"Archives of Toxicology"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/096032718500400605"},{"key":"atypb13","first-page":"462","volume":"23","author":"Marrs TC","year":"1985","journal-title":"Journal of Toxicology-Clinical Toxicology"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(83)90307-1"},{"key":"atypb15","first-page":"125","volume":"28","author":"Jandorf BJ","year":"1946","journal-title":"Journal of Industrial Hygiene and Toxicology"},{"key":"atypb16","first-page":"109","volume":"89","author":"Rose CL","year":"1947","journal-title":"Journal of Pharmacology"},{"key":"atypb17","first-page":"168","volume":"249","author":"Graffe W.","year":"1964","journal-title":"Experimentelle Pathologie"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(82)90141-2"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1177\/096032718600500501"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(84)90034-1"},{"key":"atypb21","first-page":"510","volume":"78","author":"Malz E.","year":"1962","journal-title":"Folia Haematolgica"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(66)90305-4"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1966.47"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(69)90170-8"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/BF01946202"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1007\/BF00569237"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294993"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400010664"},{"key":"atypb29","first-page":"583","author":"Ballantyne B.","year":"1983","journal-title":"evelopments in the Science and Practice of Toxicology"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1021\/ac60004a018"},{"key":"atypb31","first-page":"166","volume":"44","author":"Feldstein M.","year":"1954","journal-title":"Journal of Laboratory and Clinical Chemistry"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(84)90008-8"},{"key":"atypb33","unstructured":"Paulet G. L'Intoxication Cyanhydrique et son Traitement, p. 60.             Paris: Masson et Cie.           1960."}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718700600206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718700600206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:50:19Z","timestamp":1777449019000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718700600206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1177\/096032718700600206"],"URL":"https:\/\/doi.org\/10.1177\/096032718700600206","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}