{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:49:29Z","timestamp":1777668569130,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1987,5,1]],"date-time":"1987-05-01T00:00:00Z","timestamp":546825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:p>The solubility of two industrial forms of beryllium, i.e. particles of metal powder and particles of hot-pressed beryllium, was investigated using in vivo and in vitro models. In the in vivo model, baboons and rats were used and were injected via the trachea with amounts of beryllium equivalent to 100, 500 and 1000 fold the maximum permissible concentration (MPC) recommended by the US Occupational Safety and Health Administration. In vivo experiments showed that in both species the daily beryllium solubility rates were about 5 x 10-6 for metal particles and that in rats the daily beryllium solubility rate was about 5 x 10-5 for the hot-pressed particles. During the 10 months of the experiment with baboons, urinary excretion of beryllium was proportional to the amount administered. With regard to results for the in vitro models, the outcome of the acellular dissolution test using a serum simulant was not consistent with the in vivo results, though a cellular model using cultured macrophages showed the same trends in the dissolution rates for the two forms of beryllium as those observed in vivo. This result suggests that a cellular rather than an acellular dissolution model would be better at predicting solubility of beryllium compounds in the lungs.<\/jats:p>","DOI":"10.1177\/096032718700600311","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"233-240","source":"Crossref","is-referenced-by-count":22,"title":["Beryllium Metal Solubility in the Lung, Comparison of Metal and Hot-pressed Forms by in vivo and in vitro Dissolution Bioassays"],"prefix":"10.1177","volume":"6","author":[{"given":"S.","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique, Institut de Protection et de S\u00fbret\u00e9 Nucl\u00e9aire, D\u00e9partement de Protection Sanitaire, Service de Pathologie Exp\u00e9rimentale, Section de Toxicologie et de Canc\u00e9rologie Exp\u00e9rimentale, BP 12, F. 91680, Bruy\u00e8res le Chatel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"M\u00e9tivier","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique, Institut de Protection et de S\u00fbret\u00e9 Nucl\u00e9aire, D\u00e9partement de Protection Sanitaire, Service de Pathologie Exp\u00e9rimentale, Section de Toxicologie et de Canc\u00e9rologie Exp\u00e9rimentale, BP 12, F. 91680, Bruy\u00e8res le Chatel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lantenois","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique, Laboratoire d'Analyses de Biologie M\u00e9dicale, Centre d'Etude de Vaujours, BP 7, F. 77181, Courtry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Boyer","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique, Laboratoire d'Analyses de Biologie M\u00e9dicale, Centre d'Etude de Vaujours, BP 7, F. 77181, Courtry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Nolib\u00e9","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique, Institut de Protection et de S\u00fbret\u00e9 Nucl\u00e9aire, D\u00e9partement de Protection Sanitaire, Service de Pathologie Exp\u00e9rimentale, Section de Toxicologie et de Canc\u00e9rologie Exp\u00e9rimentale, BP 12, F. 91680, Bruy\u00e8res le Chatel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Masse","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique, Institut de Protection et de S\u00fbret\u00e9 Nucl\u00e9aire, D\u00e9partement de Protection Sanitaire, Service de Pathologie Exp\u00e9rimentale, Section de Toxicologie et de Canc\u00e9rologie Exp\u00e9rimentale, BP 12, F. 91680, Bruy\u00e8res le Chatel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(59)90154-7"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.63.3.309"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(80)90009-2"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(80)90004-3"},{"key":"atypb5","unstructured":"Parkes WR Beryllium disease. In Occupational Lung Disorders, 2nd edn, pp. 333-358. London: Butterworths, 1983."},{"key":"atypb6","volume-title":"A contribution to the epidemiology of beryllium disease","author":"Preuss OP","year":"1984"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/occmed\/27.2.57","volume":"27","author":"Williams WJ","year":"1977","journal-title":"Journal of the Society of Occupational Medicine"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198303000-00012"},{"key":"atypb9","volume-title":"First International Symposium on Toxicology","author":"Reeves AL"},{"key":"atypb10","unstructured":"Iarc. Beryllium and beryllium compounds. In Some Metals and Metallic Compounds, vol. 23, pp. 143-204. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Lyons: IARC, 1980."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90182-0"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90150-1"},{"key":"atypb13","first-page":"97","volume":"23","author":"Fritsch P.","year":"1975","journal-title":"Biomedicine"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-197305000-00004"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.3109\/01902148409087905"},{"key":"atypb16","volume-title":"Occupational safety and health standards. Occupational Safety and Health Report","author":"Bureau of National Affairs Inc.","year":"1979"},{"key":"atypb17","first-page":"401","volume":"35","author":"M\u00e9tivier H.","year":"1978","journal-title":"Health Physics"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4049\/jimmunol.86.2.133","volume":"86","author":"Myrvik QN","year":"1961","journal-title":"Journal of Immunology"},{"key":"atypb19","first-page":"121","volume":"17","author":"Hurlbut JA","year":"1978","journal-title":"Atomic Absorption Newsletter"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/BF01270905"},{"key":"atypb21","volume-title":"L'exposition au beryllium en hygi\u00e8ne industrielle","author":"Lantenois G.","year":"1983"},{"key":"atypb22","volume-title":"Proceedings of the Second International Workshop on Lung Dosimetry","author":"Bailey MR"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(76)90107-9"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(85)90025-8"},{"key":"atypb25","volume-title":"Berylliose pulmonaire, induction exp\u00e9rimentale et d\u00e9tection pr\u00e9coce","author":"Andr\u00e9 S.","year":"1984"}],"container-title":["Human Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718700600311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718700600311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:50:24Z","timestamp":1777449024000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718700600311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["10.1177\/096032718700600311"],"URL":"https:\/\/doi.org\/10.1177\/096032718700600311","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}