{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:51:56Z","timestamp":1777668716842,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>The effect of radiotherapy on the pulmonary damage caused by paraquat (24% solution of 1,1'dimethyl-4,4'-bipyridylium dichloride) was investigated in a preliminary series of nine patients. Paraquat intoxication was diagnosed by quantitative analysis of urine and plasma using colorimetry after extraction of a cation exchange column. The irradiation was given as a planned procedure from day 2 in cases 1 to 7, and after changes in chest X-ray were recognized in cases 8 and 9. A cobalt-60 unit with opposed anterior and posterior portals was used to give a total dose of 12.50 Gy (uncorrected) over 10 fractions, sparing the pericardium and mediastinum as much as possible. Each fraction consisted of 1.25 Gy (125 rad) given once a day, alternating between the left and right lungs.<\/jats:p>\n                  <jats:p>Radiological diagnosis consisted of clear chest X-rays (cases 2 to 4), pulmonary oedema (cases 7 and 9) and interstitial infiltrates (cases 1, 5, 6 and 8). Cases 1, 5, and 8 survived. Case 8 had residual interstitial infiltrates three months after ingestion but these had cleared one month later, suggesting that the diagnosis of irreversible fibrosis should only be made after a follow-up period of at least one year. The results have failed to show a definite benefit, but do support the fact that radiotherapy should be assessed carefully in a randomized trial which is now in progress.<\/jats:p>","DOI":"10.1177\/096032718800700405","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"325-332","source":"Crossref","is-referenced-by-count":20,"title":["Radiotherapy for the Treatment of Pulmonary Complications of Paraquat Poisoning"],"prefix":"10.1177","volume":"7","author":[{"given":"A.R.","family":"Talbot","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan, R.O.C. 50022"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C. 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