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The present recommendations are based largely on epidemiological studies of liver damage.<\/jats:p>\n                  <jats:p>Recent investigations indicate that alcoholic brain damage is much more common than previously suspected. More information is required about its natural history and the characteristics of individuals most likely to suffer damage.<\/jats:p>\n                  <jats:p>\n                    Thiamin (vitamin B\n                    <jats:sub>1<\/jats:sub>\n                    ) deficiency has long been associated with brain damage and may result from a number of additive causes in the alcoholic patient. New information indicating damage to the protein moeity of some of the thiamin-using enzymes has been reviewed, as have possible mechanisms of brain cell necrosis.\n                  <\/jats:p>","DOI":"10.1177\/096032718800700513","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"455-463","source":"Crossref","is-referenced-by-count":20,"title":["Alcohol and Brain Damage"],"prefix":"10.1177","volume":"7","author":[{"given":"A.D.","family":"Thomson","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Greenwich District Hospital, Vanbrugh Hill, London, SE10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.E.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London, SE5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jeyasingham","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London, SE5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.K.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Elmdene Alcohol treatment Unit, Bexley Hospital, Old Bexley Lane, Bexley, Kent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,9,1]]},"reference":[{"key":"atypb1","unstructured":"Royal College of Physicians. 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