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A dose-related increase of inhibition of replication index (P &lt; 0.01) and cell division (P &lt; 0.001) was observed. The frequencies of abnormal cells and chromosomal aberrations such as chromatid and chromosome breaks, dicentrics, triradial and quadriradial configurations were increased significantly (P &lt; 0.001), as were micronucleus counts (P &lt; 0.001) and sister chromatid exchanges (P &lt; 0.001). Endoreduplication, an extremely rare spontaneous event in human lymphocytes, was observed in a few cases at all dose levels. The effects were more pronounced in lymphocytes obtained from habitual smokers.<\/jats:p>","DOI":"10.1177\/096032718900800503","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"349-353","source":"Crossref","is-referenced-by-count":17,"title":["Cytotoxic Effects of Trimethyltin Chloride on Human Peripheral Blood Lymphocytes in vitro"],"prefix":"10.1177","volume":"8","author":[{"given":"B.B.","family":"Ghosh","sequence":"first","affiliation":[{"name":"Human Genetics Unit, Centre of Advanced Study, Cell and Chromosome Research, Department of Botany, University of Calcutta, Calcutta-700019, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Talukder","sequence":"additional","affiliation":[{"name":"Human Genetics Unit, Centre of Advanced Study, Cell and Chromosome Research, Department of Botany, University of Calcutta, Calcutta-700019, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Human Genetics Unit, Centre of Advanced Study, Cell and Chromosome Research, Department of Botany, University of Calcutta, Calcutta-700019, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,9,1]]},"reference":[{"key":"atypb1","volume-title":"Tin and organotin compounds. 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