{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:56:12Z","timestamp":1777668972607,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Toxicology"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>1 Patients who have taken canthaxanthin and beta-carotene to avert phototoxicity have been monitored by electroretinographic testing.<\/jats:p>\n                  <jats:p>2 Patients took the compounds only during the summer months, but were monitored for more than 1 year to determine if seasonal changes in the ERG were visible.<\/jats:p>\n                  <jats:p>3 The characteristic refractile retinal crystals reduced during the winter.<\/jats:p>\n                  <jats:p>4 The scotopic b-wave amplitude increased during the winter, whether evoked by red or blue flashes.<\/jats:p>\n                  <jats:p>5 No other ERG parameter altered.<\/jats:p>\n                  <jats:p>6 Changes noted in 3 and 4 above are reversible.<\/jats:p>\n                  <jats:p>7 A dose\/ERG-amplitude response relationship was established, but no correlation between blood level or total cumulative dose and b-wave amplitude could be found.<\/jats:p>\n                  <jats:p>8 It is suggested that the M\u00fcller cells concentrate canthaxanthin and this is the mechanism which affects the ERG.<\/jats:p>","DOI":"10.1177\/096032718900800603","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"439-450","source":"Crossref","is-referenced-by-count":24,"title":["Monitoring of Patients taking Canthaxanthin and Carotene: An Electroretinographic and Ophthalmological Survey"],"prefix":"10.1177","volume":"8","author":[{"given":"G.B.","family":"Arden","sequence":"first","affiliation":[{"name":"Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.O.A.","family":"Oluwole","sequence":"additional","affiliation":[{"name":"Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Polkinghorne","sequence":"additional","affiliation":[{"name":"Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Bird","sequence":"additional","affiliation":[{"name":"Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Barker","sequence":"additional","affiliation":[{"name":"Pennsylvania College of Optometry Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.G.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St. Thomas' Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.M.","family":"Hawk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St. Thomas' Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,11,1]]},"reference":[{"key":"atypb1","first-page":"304","volume":"28","author":"Barker FM","journal-title":"Investigative Ophthalmology and Visual Science Suppl."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1970.33.3.323"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/289489a0"},{"key":"atypb4","first-page":"189","volume":"225","author":"Daicker B.","year":"1987","journal-title":"Ophthalmology"},{"key":"atypb5","first-page":"58","volume":"106","author":"Harnois C.","year":"1988","journal-title":"Ophthalmology"},{"key":"atypb6","first-page":"335","volume":"29","author":"Malenfant M.","journal-title":"Investigative Ophthalmology and Visual 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Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718900800603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032718900800603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:51:45Z","timestamp":1777449105000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032718900800603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1177\/096032718900800603"],"URL":"https:\/\/doi.org\/10.1177\/096032718900800603","relation":{},"ISSN":["0144-5952"],"issn-type":[{"value":"0144-5952","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}