{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:14:27Z","timestamp":1777666467741,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:p>\n                    1 The approximate lethal dose (ALD) of six chlorinated hydrocarbons via the intratracheal route has been determined in rats and compared with published oral LD\n                    <jats:sub>50<\/jats:sub>\n                    values.\n                  <\/jats:p>\n                  <jats:p>2 The compounds tested in this study were dichloromethane, perchloroethylene, trichloroethylene, carbon tetrachloride, chloroform and ethylene dichloride.<\/jats:p>\n                  <jats:p>3 A method of administering the materials intratracheally to unanaesthetized animals was developed.<\/jats:p>\n                  <jats:p>\n                    4 The intratracheal ALD of the chlorinated hydrocarbons ranged from 3.1 to 17.5% of the oral LD\n                    <jats:sub>50<\/jats:sub>\n                    and death was peracute.\n                  <\/jats:p>\n                  <jats:p>5 Aspiration of chlorinated hydrocarbons may present more of a hazard than oral toxicity and should be considered when rendering first aid or emergency medical treatment.<\/jats:p>","DOI":"10.1177\/096032719201100305","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"173-177","source":"Crossref","is-referenced-by-count":1,"title":["Acute Toxicity in Rats of Chlorinated Hydrocarbons Given via the Intratracheal Route"],"prefix":"10.1177","volume":"11","author":[{"given":"Leslie P.","family":"McCarty","sequence":"first","affiliation":[{"name":"Health and Environmental Sciences and Occupational Health, The Dow Chemical Company Midland, MI 48674 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donal C.","family":"Flannagan","sequence":"additional","affiliation":[{"name":"Health and Environmental Sciences and Occupational Health, The Dow Chemical Company Midland, MI 48674 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scot A.","family":"Randall","sequence":"additional","affiliation":[{"name":"Health and Environmental Sciences and Occupational Health, The Dow Chemical Company Midland, MI 48674 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Health and Environmental Sciences and Occupational Health, The Dow Chemical Company Midland, MI 48674 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-21-5-803"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(59)90099-7"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-1124(76)80307-3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-1124(77)80211-6"},{"key":"atypb5","doi-asserted-by":"crossref","unstructured":"Berkow R. Merck Manual, 15 ed, p. 2551. Rahway, NJ: Merck & Co., Inc., 1987.","DOI":"10.1016\/0002-9394(88)90272-3"},{"key":"atypb6","first-page":"415","volume":"25","author":"Deichmann WB","year":"1943","journal-title":"Journal of Industrial Hygiene and Toxicology"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550060302"},{"key":"atypb8","unstructured":"Torkelson TR & Rowe VK Halogenated aliphatic hydrocarbons containing chlorine bromine and iodine . In: Patty's Industrial Hygiene and Toxicology, 3rd ed, eds Clayton GD & Clayton FE, pp. 3433-601. New York: John Wiley & Sons, 1981."},{"key":"atypb9","unstructured":"Steel Rgd & Torrie JH Principles and Procedures of Statistics, 2nd edn, pp. 43-5. New York: McGraw-Hill, 1980."},{"key":"atypb10","unstructured":"Thompson WL Recognition, treatment and prevention of poisoning, In: Textbook of Critical Care, 1st edn, eds Shoemaker WC Thompson WL & Holbrook PR, pp. 801-32. Philadelphia : W. B. Saunders Co., 1984."}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032719201100305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032719201100305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:42:56Z","timestamp":1777448576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032719201100305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1177\/096032719201100305"],"URL":"https:\/\/doi.org\/10.1177\/096032719201100305","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}