{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:16:23Z","timestamp":1777666583820,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1993,3]]},"abstract":"\n 1 Following daily administration to male albino rats for 2 weeks, \u03b2-naphthoflavone (25 and 60 mg kg\n -1<\/jats:sup>\n , i.p.) and phenobarbitone (100 mg kg\n -1<\/jats:sup>\n , p.o.) produced their characteristic patterns of induction of P450-related enzyme activities. \u03b2-naphthoflavone also induced p-nitrophenol glucuronidation by 160% over controls, while phenobarbitone produced only a 45% induction of this conjugation activity.\n <\/jats:p>\n \n 2 \u03b2-Naphthoflavone produced significant reductions in plasma thyroxine (T\n 4<\/jats:sub>\n ) concentrations on days 4 and 16 and also decreased tri-iodothyronine (T\n 3<\/jats:sub>\n ) on day 4. Thyroid-stimulating hormone (TSH) was significantly increased on day 16 by the higher dose of \u03b2-naphthoflavone. Thyroid weight was significantly increased at both dose levels on day 16 and liver weight was significantly increased on both days 4 and 16. No histopathological changes were seen in the liver or pituitary, but 30% of the animals showed minimal to mild follicular epithelial hypertrophy of the thyroid gland.\n <\/jats:p>\n \n 3 Phenobarbitone had no effect on T\n 4<\/jats:sub>\n concentrations, but significantly decreased T\n 3<\/jats:sub>\n on day 4. TSH increased by 60% on day 16, but was not statistically significant compared with controls. Thyroid weight was significantly increased on day 16 and liver weight was significantly increased on days 4 and 16. Mild to moderate thyroid follicular epithelial hypertrophy and moderate hepatocyte hypertrophy occurred in all animals. No histopathological changes were seen in the pituitary.\n <\/jats:p>\n \n 4 The early changes in T\n 4<\/jats:sub>\n and\/or T\n 3<\/jats:sub>\n were probably due to increased hepatic clearance by induction of thyroxine glucuronidation with both compounds. Thyroid hypertrophy would be expected to follow as a result of activation of the hypothalamic-pituitary-thyroid axis. Data for the two compounds suggest some variation in the precise mechanism of action, which has not yet been fully elucidated.\n <\/jats:p>","DOI":"10.1177\/096032719301200210","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"153-158","source":"Crossref","is-referenced-by-count":14,"title":["The Effects on Rat Thyroid Function of an Hepatic Microsomal Enzyme Inducer"],"prefix":"10.1177","volume":"12","author":[{"given":"S.","family":"Johnson","sequence":"first","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"McKillop","sequence":"additional","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Miller","sequence":"additional","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.K.","family":"Smith","sequence":"additional","affiliation":[{"name":"ICI Pharmaceuticals, Safety of Medicines Department, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0031-6997(25)06850-4","volume":"33","author":"Cavalieri RR","year":"1981","journal-title":"Pharmacological 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