{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:17:58Z","timestamp":1777666678483,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>\n                    1 A case of severe mercuric chloride poisoning with clinical signs of mucosal damage of the gastrointestinal tract and anuric renal failure, is presented. The initial whole blood mercury concentration was 14,300 ?g 1\n                    <jats:sup>-1<\/jats:sup>\n                    . This concentration is supposed to be associated with fatal outcome due to multiple organ failure.\n                  <\/jats:p>\n                  <jats:p>2 Because of anuric renal failure, haemodialysis was necessary. Kidney function returned to normal within 10 days. Haemodialysis proved to be ineffective with regard to total mercury elimination.<\/jats:p>\n                  <jats:p>3 Treatment with DMPS was started because of very severe poisoning, anuric renal failure and optimistic reports on the 'new' chelating agent 2,3-dimercapto-1-propanesulphonic acid (DMPS) in mercury poisoning. DMPS was administered by parenteral route initially and was continued thereafter by oral route, until whole blood and urine mercury concentrations had decreased below a level considered as toxic. Except for a temporary pruritic erythema of the skin, no side effects of DMPS treatment were observed.<\/jats:p>\n                  <jats:p>4 The clinical course was mild, despite continuing high whole blood mercury concentrations, Recovery was uneventful and complete. DMPS treatment, administered by intravenous and oral route, was shown to be an effective alternative for BAL in life-threatening mercuric chloride intoxication.<\/jats:p>\n                  <jats:p>5 The pharmacokinetic data presented in this case report suggest that non-renal mercury clearance may considerably exceed renal mercury clearance.<\/jats:p>","DOI":"10.1177\/096032719401300103","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"11-16","source":"Crossref","is-referenced-by-count":38,"title":["Mercury Kinetics in a Case of Severe Mercuric Chloride Poisoning Treated with Dimercapto-1-propane Sulphonate (DMPS)"],"prefix":"10.1177","volume":"13","author":[{"given":"A.E.","family":"Toet","sequence":"first","affiliation":[{"name":"National Poison Control Center, National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720 BA Bilthoven, Department of Intensive Care and Clinical Toxicology, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.J.F.","family":"Savelkoul","sequence":"additional","affiliation":[{"name":"National Poison Control Center, National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720 BA Bilthoven, Department of Intensive Care and Clinical Toxicology, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Meulenbelt","sequence":"additional","affiliation":[{"name":"National Poison Control Center, National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720 BA Bilthoven, Department of Intensive Care and Clinical Toxicology, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM195908202610815","volume":"261","author":"Lowe B.","year":"1959","journal-title":"The New England Journal of Medicine"},{"key":"atypb2","first-page":"261","volume":"18","author":"Winek CL","year":"1981","journal-title":"Toxicology"},{"key":"atypb3","unstructured":"Gosselin RE , Hodge HC, Smith RP, Gleason MN Clinical Toxicology of Commercial Products, 5th ed. Baltimore, Williams and Wilkins , 1984; pp. 262-75."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197107012850102"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3565(25)32633-9","volume":"218","author":"Clarkson TW","year":"1981","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700050308"},{"key":"atypb7","unstructured":"Klaassen CD Goodman & Gilman's, The Pharmacological Basis of Therapeutics , 8th ed. New York, Pergamon Press, 1990; pp. 1598-1602."},{"key":"atypb8","unstructured":"Goyer RA Casarett and Doull's Toxicology, 4th ed. New York, Pergamon Press, 1990, pp. 646-51."},{"key":"atypb9","unstructured":"Goldfrank LR , Bresnitz EA, Howland MA & Weisman RS Goldfrank's Toxicologic Emergencies, 4th ed. Connecticut, Appleton & Lange, 1990, pp. 641-8."},{"key":"atypb10","unstructured":"Aronow R. Haddad's Clinical Management of Poisoning and Drug Overdose, 2nd ed. Philadelphia, W.B. Saunders, 1990, pp. 1002-9."},{"key":"atypb11","unstructured":"Nadig J. , Knutti R. & Hany A. DMPS-Behandlung bei einer akuten Sublimat-(Quecksilberchlorid-) Vergiftung . Schweizerische Medizinische Wochenschrift 1985; 115: 507-11."},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380220093029"},{"key":"atypb13","volume-title":"Seminar The Use of Chelating Agents in Poisoning","author":"Ashton CE"},{"issue":"4","key":"atypb14","first-page":"81","volume":"9","author":"Mesman BB","year":"1969","journal-title":"Atomic Absorption Newsletter"},{"key":"atypb15","first-page":"155","volume":"22","author":"Proost JH","year":"1992","journal-title":"Biology and Medicine"},{"key":"atypb16","first-page":"189","volume":"26","author":"Sauder Ph","year":"1988","journal-title":"Clinical Toxicology"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/BF01721058"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.3109\/15563658308990064"},{"key":"atypb19","first-page":"31","volume":"22","author":"Lund ME","year":"1984","journal-title":"Clinical Toxicology"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-4-451"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1177\/096032718300200214"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259951"},{"key":"atypb23","volume-title":"Seminar The Use of Chelating Agents in Poisoning","author":"Kemper FH"},{"key":"atypb24","first-page":"346","volume":"24","author":"Cikrt M.","year":"1980","journal-title":"Immunology"},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0022-3565(25)32560-7","volume":"217","author":"Planas-Bohne F.","year":"1981","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.3109\/15563658208990379"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1007\/BF01705428"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333982"},{"key":"atypb29","first-page":"245","author":"Cherian MG","year":"1988","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198205000-00002"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5694\/j.1326-5377.1978.tb131407.x","volume":"2","author":"Cugh KS","year":"1978","journal-title":"Medical Journal of Australia"},{"key":"atypb32","unstructured":"Dukes Mng. 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