{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:18:46Z","timestamp":1777666726449,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:p>1 A detailed study of the urinary excretion pattern of porphyrins in humans chronically exposed to As via drinking water was performed using high performance liquid chromatography (HPLC)<\/jats:p>\n                  <jats:p>\n                    2 Thirty-six individuals (15 men and 21 women) were selected from a town which had 0.400 mg L\n                    <jats:sup>-1<\/jats:sup>\n                    of As in drinking water. The control group consisted of thirty-one individuals (13 men and 18 women) whose As concentration in drinking water was 0.020 mg L\n                    <jats:sup>-1<\/jats:sup>\n                    .\n                  <\/jats:p>\n                  <jats:p>3 The major abnormalities in the urinary porphyrin excretion pattern observed in arsenic-exposed individuals were: (a) significant reductions in coproporphyrin III excretion resulting in decreases in the COPRO III\/COPRO I ratio, and (b) significant increases in uroporphyrin excretion. Both alterations were responsible for the decrease in the COPRO\/URO ratio.<\/jats:p>\n                  <jats:p>\n                    4 No porphyrinogenic response was found in individuals with urinary As concentrations below 1,000 \u03bcg of As g\n                    <jats:sup>-1<\/jats:sup>\n                    of creatinine, However, as arsenic concentrations exceeded this value, the excretion of porphyrins (except coproporphyrin III) increased proportionally.\n                  <\/jats:p>\n                  <jats:p>5 The prevalence of clinical signs of arsenicism showed a direct relationship to both As concentration in urine and time-weighted exposure to As. A direct relationship between time-weighted exposure and alterations in urinary porphyrin excretion ratios was also observed.<\/jats:p>\n                  <jats:p>6 The alterations found are compatible with a lower uroporphyrinogen decarboxylase activity in arsenic-exposed individuals. However, the similarities in the urinary porphyrin excretion pattern between As-exposed individuals and Dubin-Johnson syndrome patients suggest that impairments in the excretion of coproporphyrin isomers may also contribute to the pattern observed.<\/jats:p>","DOI":"10.1177\/096032719401301204","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"839-847","source":"Crossref","is-referenced-by-count":63,"title":["Altered Urinary Porphyrin Excretion in a Human Po p ulation Chronically Exposed to Arsenic in Mexico"],"prefix":"10.1177","volume":"13","author":[{"given":"Gonzalo G.","family":"Garc\u00eda-Vargas","sequence":"first","affiliation":[{"name":"MRC Toxicology Unit, Hodkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz M.","family":"Del Razo","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicologia Ambiental, Departamento de Farmacologia y Toxicologia, CINVESTAV-IPN, P.O. Box 14-740, Mexico, DF 07000, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano E.","family":"Cebri\u00e1n","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicologia Ambiental, Departamento de Farmacologia y Toxicologia, CINVESTAV-IPN, P.O. Box 14-740, Mexico, DF 07000, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnulfo","family":"Albores","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicologia Ambiental, Departamento de Farmacologia y Toxicologia, CINVESTAV-IPN, P.O. Box 14-740, Mexico, DF 07000, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ostrosky-Wegman","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas, UNAM, M\u00e9xico, DF, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Montero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas, UNAM, M\u00e9xico, DF, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Gonsebatt","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas, UNAM, M\u00e9xico, DF, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang K.","family":"Lim","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"De Matteis","sequence":"additional","affiliation":[{"name":"MRC Toxicology Unit, Hodkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"atypb1","first-page":"702","volume":"99","author":"Borgono JM","year":"1971","journal-title":"Revista M\u00e9dica de Chile"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/096032718300200110"},{"key":"atypb3","unstructured":"Tseng WP, Chu HM, How SW et al. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. Journal of the National Cancer Institute 1968; 40: 453-63."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(74)90148-0"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.75121"},{"key":"atypb6","first-page":"28","volume":"2","author":"Thompson Rhs.","year":"1948","journal-title":"Biochemistry Society Symposium"},{"key":"atypb7","unstructured":"Webb JL Enzyme and Metabolic Inhibitors. 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