{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:21:27Z","timestamp":1777666887815,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1995,1]]},"abstract":"\n 1 The therapeutic efficacy of combined treatment of sodium nitrite (NaNO\n 2<\/jats:sub>\n ) and 4-dimethylaminophenol (DMAP) or hydroxylamine (H\n 2<\/jats:sub>\n NOH) was investigated in potassium cyanide (KCN) intoxication in male rats.\n <\/jats:p>\n \n 2 Therapy with NaNO\n 2<\/jats:sub>\n (0.27 mmol kg\n -1<\/jats:sup>\n ) + DMAP (0.09 mmol kg\n -1<\/jats:sup>\n ) or NaNO\n 2<\/jats:sub>\n + H\n 2<\/jats:sub>\n NOH (0.09 mmol kg\n -1<\/jats:sup>\n , produced a protection index (ratio of LD\n 50<\/jats:sub>\n of KCN in rats receiving therapy to an LD\n 50<\/jats:sub>\n of KCN in rats given only 0.9% saline) of 2.5 and 2.0 respectively.\n <\/jats:p>\n \n 3 Both the regimens exhibited a beneficial effect in terms of improving the survival time and postural defects in rats exposed to 2 LD\n 50<\/jats:sub>\n KCN.\n <\/jats:p>\n \n 4 NaNO\n 2<\/jats:sub>\n + DMAP showed a significant protective effect in the disposition of the plasma cyanide level at different time intervals.\n <\/jats:p>\n \n 5 The NaNO\n 2<\/jats:sub>\n + DMAP regimen was superior to NaNO\n 2<\/jats:sub>\n + H\n 2<\/jats:sub>\n NOH in terms of reactivating the inhibited brain cytochrome oxidase enzyme.\n <\/jats:p>\n \n 6 The addition of sodium thiosulphate (Na\n 2<\/jats:sub>\n S\n 2<\/jats:sub>\n O\n 3<\/jats:sub>\n ) in both the regimens increased the degree of protection.\n <\/jats:p>\n \n 7 The results suggest that combined therapy with NaNO\n 2<\/jats:sub>\n + DMAP could significantly reduce the toxic effects of cyanide, compared with NaNO\n 2<\/jats:sub>\n +H\n 2<\/jats:sub>\n NOH treatment.\n <\/jats:p>","DOI":"10.1177\/096032719501400107","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"29-33","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic efficacy of sodium nitrite and 4-dimethylaminophenol or hydroxylamine co-administration against cyanide poisoning in rats"],"prefix":"10.1177","volume":"14","author":[{"given":"R.","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.24.040184.002315"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1952.02930190015004"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(69)90170-8"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00351825"},{"key":"atypb5","first-page":"115","volume":"211","author":"Kiese M.","year":"1950","journal-title":"Archiv f\u00fcr experimentelle pathologie und Pharmakologie"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00347867"},{"key":"atypb7","first-page":"230","volume":"14","author":"Bhattacharya R.","year":"1991","journal-title":"Archives of Toxicology (Suppl)"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1177\/096032719301200107"},{"key":"atypb9","first-page":"627","volume":"4","author":"Bhattacharya R.","year":"1992","journal-title":"Biochemistry International"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1965.10480843"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)73873-8"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00569237"},{"key":"atypb13","first-page":"166","volume":"44","author":"Feldstein M.","year":"1954","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1021\/ac60333a029"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90158-3"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)44883-1"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57021-6"},{"key":"atypb18","unstructured":"Way JL, Leung P., Sylvester DM, Burrow G. et al. Methaemoglobin formation in the treatment of acute cyanide intoxication In Clinical and Experimental Toxicology of Cyanides, eds B. Ballantyne & TC Mars pp. 402- 12. Bristol : John Wright 1987."},{"key":"atypb19","unstructured":"Bright JE A prophylaxis for cyanide poisoning In Clinical and Experimental Toxicology of Cyanides eds B Ballantyne and TC Marrs. pp. 359- 82. 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