{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:22:13Z","timestamp":1777666933570,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>1 Rat hepatic cytochrome P450s induced by dipyrone were studied enzymatically, immunochemically and immunohistochemically.<\/jats:p>\n                  <jats:p>2 Dipyrone administered to male Wistar rats increased pentoxyresorufin O-depentylation (PROD), ethoxyresor ufin O-deethylation (EROD) and 7-ethoxycoumarin O- deethylation (ECOD) activities up to 44-, 1.9-, and 2.6-fold, respectively. Aryl hydrocarbon hydroxylase (AHH) activ ity was not affected.<\/jats:p>\n                  <jats:p>3 Immunoinhibition with the monoclonal antibody (Mab) 2-66-3 (to CYP2B1\/2) markedly decreased PROD and EROD activities, but not AHH activity. The Mab 1-7-1 (to CYP1A1\/2) was without effect.<\/jats:p>\n                  <jats:p>4 Histochemically, the Mab 2-66-3 gave a strong and uniform staining in livers from dipyrone-treated rats, whereas the Mab 1-7-1 gave a positive reaction in a narrow perivenous strip.<\/jats:p>\n                  <jats:p>5 The induction pattern as well as inhibition by the Mabs convincingly demonstrate the predominant production of CYP2B1\/2 in the induction spectrum of dipyrone. The increase in enzyme activities other than PROD may be due to the overlapping substrate specificity of CYP2B1\/2 enzymes. The immunohistochemical analysis also indi cated the participation of CYP1A1\/2.<\/jats:p>","DOI":"10.1177\/096032719601500108","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"45-50","source":"Crossref","is-referenced-by-count":8,"title":["Immunohistochemical properties of dipyrone-induced cytochromes P450 in rats"],"prefix":"10.1177","volume":"15","author":[{"given":"H.","family":"Kraul","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Toxicology, University of Oulu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pasanen","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Toxicology, University of Oulu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sigusch","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Toxicology, University of Oulu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Stenb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Oulu, SF-90220 Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-S.","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HV","family":"Gelboin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Pelkonen","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Toxicology, University of Oulu"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1993.12.1"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00562499"},{"key":"atypb3","first-page":"849","volume":"27","author":"Ackermann E.","year":"1972","journal-title":"Zeitsch Gesamte Innere Med"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1021\/bi00266a045"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0031-6997(25)07146-7","volume":"19","author":"Conney AH","year":"1967","journal-title":"Pharmacol Rev"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-021523-5.50023-7"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1950.285.1-3.97"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1980.tb01813.x"},{"key":"atypb9","first-page":"1262","volume":"26","author":"Remmer H.","year":"1976","journal-title":"Arzneimittelforschung"},{"key":"atypb10","first-page":"787","volume":"40","author":"Ortweiler W.","year":"1985","journal-title":"Pharmazie"},{"key":"atypb11","first-page":"50","volume":"40","author":"Simon HU","year":"1985","journal-title":"Pharmazie"},{"key":"atypb12","first-page":"345","volume":"24","author":"Weiss R.","year":"1974","journal-title":"Arzneimittelforschung"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90381-5"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.3109\/00498258609038986"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.6.821"},{"key":"atypb16","volume-title":"der 14C-Monomethylaminoantipyrin-Atemtest als in vivo-Parameter zur Charakterisierung der Induktion des arzneimittelabbauenden Enzymsystems beim Meerschweinchen. 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