{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:22:24Z","timestamp":1777666944181,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>A xenobiotic, well tolerated by the majority of treated patients, can cause serious complications in patients with individual susceptibility. Based on the hypothesis that such a phenomenon may occur in rare cases of rhabdo myolysis attributed to fenoverine (DCI), we designed a protocol to look for a genetic predisposition. Six patients were included who had previously had an episode of rhabdomyolysis after taking fenoverine. A seventh patient was added, who had only experienced myalgia without cytolysis. All patients were investigated by the following tests: 31-phosphorus nuclear magnetic resonance spectro scopy, histopathological examination of the muscle, muscle contraction tests and biochemical analysis of the muscle.<\/jats:p>\n                  <jats:p>All patients examined proved to have muscle abnorm alities. The pathology found varied greatly from patient to patient: mitochondrial myopathy, lipid storage myopathy, sensitivity to malignant hyperthermia or disorders of oxidative metabolism.<\/jats:p>\n                  <jats:p>The probability of finding by chance such rare muscle disorders associated with the equally rare rhabdomyo lysis attributed to fenoverine is practially zero. We conclude that there is a cause and effect link between underlying abnormalities and the muscular cytolysis attributed to fenoverine.<\/jats:p>","DOI":"10.1177\/096032719601501004","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"815-820","source":"Crossref","is-referenced-by-count":10,"title":["Research into individual predisposition to develop acute rhabdomyolysis attributed to fenoverine"],"prefix":"10.1177","volume":"15","author":[{"given":"Jacqueline","family":"Jouglard","sequence":"first","affiliation":[{"name":"Centre anti-poisons- Pharmacovigilance, h\u00f4pital Salvator, 249 bd. Sainte Marguerite, 13 009 Marseille"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Kozak-Ribbens","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale, Facult\u00e9 de m\u00e9decine, 27 bd. Jean Moulin, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"de Haro","sequence":"additional","affiliation":[{"name":"Centre anti-poisons- Pharmacovigilance, h\u00f4pital Salvator, 249 bd. Sainte Marguerite, 13 009 Marseille"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J","family":"Cozzone","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale, Facult\u00e9 de m\u00e9decine, 27 bd. Jean Moulin, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"atypb1","volume-title":"INDEX NOMINUM International Drug Directory","author":"Swiss Pharmaceutical Society","year":"1990"},{"key":"atypb2","first-page":"490","volume":"141","author":"Chichmanian RM","year":"1990","journal-title":"Annales de m\u00e9decine interne"},{"issue":"27","key":"atypb3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0248-8663(05)81587-5","volume":"14","author":"Chichmanian RM et al","year":"1992","journal-title":"Bulletin de la soci\u00e9t\u00e9 nationale francaise de m\u00e9decine interne"},{"key":"atypb4","series-title":"Malignant Hyperthermias","volume-title":"Investigation and diagnosis of malignant and exercise hyperthermias","author":"Kozak-Ribbens G.","year":"1993"},{"key":"atypb5","first-page":"115","volume":"40","author":"Begaud B.","year":"1985","journal-title":"Th\u00e9rapie"},{"key":"atypb6","first-page":"918","volume":"36","author":"Perrot D.","year":"1985","journal-title":"Encyclop\u00e9die m\u00e9dicochirurgicale- Anesth\u00e9sie-r\u00e9animation (Paris)"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01760406"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1203"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.1.72"},{"key":"atypb10","first-page":"518","volume":"985","author":"Kozak-Reiss G.","year":"1990","journal-title":"Journal of Neurological Sciences"},{"issue":"12","key":"atypb11","first-page":"17p","volume":"364","author":"Kozak-Reiss G.","year":"1991","journal-title":"Encyclop\u00e9die m\u00e9dicochirurgicale- Techniques chirurgicales, Anesth\u00e9sie-r\u00e9animation (Paris)"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/56.11.1267"},{"key":"atypb13","unstructured":"Kozak-Ribbens G. Malignant hyperthermia, heat stroke and mitochondrial myopathies. VI th International Malignant Hyperthermia Workshop, Hershey (Pennsylvania), 16-20 Sept. 1992 ."},{"key":"atypb14","unstructured":"Rodet L. Incidence \u00e9lev\u00e9e de tests de contracture halothane-caf\u00e9ine posotifs chez 13 patients souffrant de rhabdomyolyse d'effort. 5\u00e8me Colloque national sur les maladies neuromusculaires, Strabourg (France) , 21-25 June 1993."},{"issue":"5132","key":"atypb15","first-page":"3","volume":"23","author":"Sporn P.","year":"1993","journal-title":"Wiener Klinische Wochenschrift"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032719601501004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032719601501004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:54Z","timestamp":1777448694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032719601501004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1177\/096032719601501004"],"URL":"https:\/\/doi.org\/10.1177\/096032719601501004","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}