{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:53:35Z","timestamp":1789692815380,"version":"4.0.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>1 The in vitro metabolism ofn-hexane was studied in rat liver, lung, brain and skeletal muscle microsomes and in microsomes prepared from cell lines expressing human cytochrome P-450 2E1 or 2B6. The hydro xylated metabolites ofn-hexane were quantified by gas chromatography-mass spectometry.<\/jats:p>\n                  <jats:p>2 Rat liver and extensor digitorum longus (EDL, fast- twitch skeletal muscle) microsomes and the CYP 2B6 microsomes produced the pre-neurotoxic metabolite of n-hexane, 2-hexanol as a major metabolite in contrast to the other rat tissues examined.<\/jats:p>\n                  <jats:p>3 Inhibition of 2- and 3-hexanol production from n- hexane by rat lung microsomes using metyrapone, an inhibitor of cytochrome P-450 2B1 activity, resulted in almost complete inhibition of lung microsomal activ ity.<\/jats:p>\n                  <jats:p>4 Production of all three hexanols was significantly increased with phenobarbital-induced rat liver micro somes, with a 10-fold increase in 2- and 3-hexanol production. A slight increase in 2-hexanol production with phenobarbital-induced rat EDL and brain micro somes was observed. No increase in n-hexane meta bolism was noted following induction with \u03b2- naphthoflavone or with ethanol.<\/jats:p>","DOI":"10.1177\/096032719701600301","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"131-137","source":"Crossref","is-referenced-by-count":24,"title":["Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers"],"prefix":"10.1177","volume":"16","author":[{"given":"Sarah J","family":"Crosbie","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PG","family":"Blain","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith M","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,3,1]]},"reference":[{"key":"atypb1","volume-title":"n-Hexane. 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