{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:26:21Z","timestamp":1777667181698,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>1 Perfluoroisobutene, a pyrolysis product of polytetra fluoroethene may cause pulmonary oedema and death when inhaled. Oral N-acetylcysteine has shown protection against inhalation of perfluoroisobutene and in this study we have tried to elucidate the mechanism by which protection is mediated.<\/jats:p>\n                  <jats:p>2 Protection against the lethal effects of inhaled per fluoroisobutene has been shown when N-acetylcys teine has been orally administered 4, 6 or 8 h before gas exposure.<\/jats:p>\n                  <jats:p>3 Plasma levels of cysteine, glutathione and N-acetylcys teine were increased for up to 7 h following oral administration of Nac.<\/jats:p>\n                  <jats:p>4 N-acetylcysteine was not detected in the bronchio alveolar lavage fluid following oral administration.<\/jats:p>\n                  <jats:p>5 Duration of protection in vivo has been related to the duration of increased thiol levels in the plasma.<\/jats:p>","DOI":"10.1177\/096032719701600410","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"212-216","source":"Crossref","is-referenced-by-count":13,"title":["Oral N-acetylcysteine protects against perfluoroisobutene toxicity in rats"],"prefix":"10.1177","volume":"16","author":[{"given":"Alison F","family":"Lailey","sequence":"first","affiliation":[{"name":"Medical Countermeasures, Chemical and Biological Defence, Defence Evaluation and Research Agency (DERA), Porton Down, Salisbury, Wilts, SP4 0JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,4,1]]},"reference":[{"key":"atypb1","first-page":"115","volume":"86","author":"Webb WR","year":"1962","journal-title":"American Review Respiratory Diseases"},{"issue":"111","key":"atypb2","first-page":"90","volume":"61","author":"Chodosh S.","year":"1980","journal-title":"European Journal of Respiratory Diseases"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1159\/000195085"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.23.040183.000511"},{"key":"atypb5","first-page":"513","volume":"42","author":"Ziment I.","year":"1988","journal-title":"Biomed-Pharmacotherapy"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1159\/000195086"},{"key":"atypb7","first-page":"2","volume":"10","author":"Unverferth DV","year":"1983","journal-title":"Seminars in Oncology"},{"key":"atypb8","first-page":"49","volume":"10","author":"Unverferth DV","year":"1983","journal-title":"Seminars in Oncology"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(82)90035-9"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90391-H"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)81085-3"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.3_Pt_1.768"},{"issue":"1","key":"atypb13","first-page":"17","volume":"10","author":"Johnston RE","year":"1983","journal-title":"Seminars in Oncology"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199120020-00004"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061422"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(66)90197-3"},{"issue":"111","key":"atypb17","first-page":"45","volume":"61","author":"Bonanomi L.","year":"1980","journal-title":"European Journal Respiratory Diseases"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510110205"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/BF00609183"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.3109\/00365519409085464"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01047464"},{"key":"atypb22","first-page":"662","volume":"12","author":"Deneke SM","year":"1995","journal-title":"Biology"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663783"},{"key":"atypb24","first-page":"73","volume":"70","author":"Cotgreave IA","year":"1987","journal-title":"European Journal Respiratory Diseases"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.7.670"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.1.152"}],"container-title":["Human &amp; 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