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DEDC at a dose of 5 mg\/kg selectively inhibited enzyme markers for CYP2E1 activity, and provided substantial protection against DCP hepato toxicity. At a higher dose (25 mg\/kg), DEDC also inhibited an enzyme marker for CYP1A2 activity and provided complete protection against DCP hepatotoxicity. It is concluded: (a) that DEDC at a dose of 5 mg\/kg is a selective CYP2E1 inhibitor in the rat in vivo; and (b) that DCP hepatotoxicity is mediated principally by CYP2E1, with a possible contribution from CYP1A2.<\/jats:p>","DOI":"10.1177\/096032719701600505","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T01:08:04Z","timestamp":1230080884000},"page":"262-266","source":"Crossref","is-referenced-by-count":23,"title":["Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-Dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat"],"prefix":"10.1177","volume":"16","author":[{"given":"Ian","family":"Stott","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Cell Biology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman W","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Biology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R","family":"Fry","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1993.tb00618.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/096032719401300408"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/1382-6689(95)00007-0"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45325-8"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0090-9556(25)06500-6","volume":"23","author":"Newton DJ","year":"1995","journal-title":"Drug Metabolism and Disposition"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90688-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(92)90082-V"},{"key":"atypb8","author":"Hammond AH","journal-title":"Toxicology"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3109\/00498259109039529"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0026-895X(25)14748-2","volume":"3","author":"Schenkman JB","year":"1967","journal-title":"Molecular Pharmacology"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)82245-5"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(94)90114-7"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90363-8"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0090-9556(25)07240-X","volume":"24","author":"Zhang X-J.","year":"1996","journal-title":"Drug Metabolism and Disposition"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.3109\/03602538909103560"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1990.tb01207.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90124-1"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1990.tb00857.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.3109\/10408449309104072"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90386-9"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.3109\/10715769609088045"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(94)02890-7"}],"container-title":["Human &amp; 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