{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:27:44Z","timestamp":1777667264523,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>\n                    An influx of neutrophils into the airways is a common feature observed during pulmonary inflammation induced by air pollutants, including sulfur dioxide and sulfates. In the present study focusing on the in vitro interactions of sodium sulfite (Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    ) with human neutrophils, we confirm results indicating that this sulfite induces superoxide production (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>7<\/jats:sup>\n                    ) by itself. We demonstrated that this response can occur more rapidly than previously reported (within 5 min), and that Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    can act as a priming agent, in a concentration-dependent fashion, to the bacterial tripeptide N-formyl-methionineleucine-phenylalanine (fMLP) by increasing O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>7<\/jats:sup>\n                    production. In addition, our results show that Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    induces gene expression in human neutrophils in a concentration-dependent manner as assessed by incorporation of 5-[\n                    <jats:sup>3<\/jats:sup>\n                    H] uridine into total RNA. However, it does not induce cell shape changes. We also demonstrated that Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    does not modulate neutrophil apoptosis nor reverse the well-known delaying effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on apoptosis. We conclude that Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    acts rapidly on neutrophil physiology, within a few minutes with respect to superoxide production, and a few hours (4 h) with respect to gene expression without altering a biological process such as the rate of apoptosis evaluated after a long period of incubation (20 h). We further conclude that Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    -induced production of O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>7<\/jats:sup>\n                    does not drive neutrophils to undergo apoptosis, a mechanism known to occur in other conditions. Therefore, the potential toxicity of Na\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>3<\/jats:sub>\n                    during pulmonary inflammation or lung-associated diseases may be related to its ability to induce superoxide production without altering neutrophil apoptosis rate.\n                  <\/jats:p>","DOI":"10.1177\/096032719801701103","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T14:52:48Z","timestamp":1484664768000},"page":"600-605","source":"Crossref","is-referenced-by-count":19,"title":["Functional responses of human neutrophils to sodium sulfite (Na2SO3) in vitro"],"prefix":"10.1177","volume":"17","author":[{"given":"Pierrette","family":"Labb\u00e9","sequence":"first","affiliation":[{"name":"Institut National de la Recherche Scientifique-Sant\u00e9                         (INRS-Sant\u00e9), Universit\u00e9duQu\u00e9bec,                         Pointe-Claire, Qu\u00e9bec, H9R 1G6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Scientifique-Sant\u00e9                         (INRS-Sant\u00e9), Universit\u00e9duQu\u00e9bec,                         Pointe-Claire, Qu\u00e9bec, H9R 1G6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix O","family":"Omara","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Scientifique-Sant\u00e9                         (INRS-Sant\u00e9), Universit\u00e9duQu\u00e9bec,                         Pointe-Claire, Qu\u00e9bec, H9R 1G6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Girard","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Scientifique-Sant\u00e9                         (INRS-Sant\u00e9), Universit\u00e9duQu\u00e9bec,                         Pointe-Claire, Qu\u00e9bec, H9R 1G6 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"atypb1","first-page":"1","volume-title":"The Neutrophil","author":"Kanwar VS","year":"1993"},{"key":"atypb2","first-page":"63","volume-title":"The Neutrophil","author":"McPhail LC","year":"1993"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80066-2"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90121-M"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4682(05)80009-1"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.3.1170.1170"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.59.3.412"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1042\/bj3250147"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4341"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3176.bloodjournal8883176"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.54.4.283"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1681\/ASN.V871091","volume":"8","author":"Kettritz R","year":"1997","journal-title":"J Am Soc Neprhol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391012"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01205-X"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.2.7865221"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070280408"},{"key":"atypb17","first-page":"465","volume":"9","author":"Miller DJ","year":"1995","journal-title":"J Hum Hypertens"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.4049\/jimmunol.156.4.1540","volume":"156","author":"Gossart S","year":"1996","journal-title":"JImmunol"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.856363"},{"key":"atypb20","first-page":"131","volume":"54","author":"IARC working group","year":"1992","journal-title":"IARC monographs on the evaluation of carcinogenic risks to human"},{"key":"atypb21","first-page":"11","volume":"9","author":"Denisov IuN","year":"1990","journal-title":"Gig Sanit"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1080\/15287399409531844"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90148-N"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.4049\/jimmunol.142.7.2438","volume":"142","author":"Naccache PH","year":"1989","journal-title":"J Immunol"},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.4049\/jimmunol.150.11.5124","volume":"150","author":"Whyte MKB","year":"1993","journal-title":"J Immunol"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)82447-1"}],"container-title":["Human &amp; 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