{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:40:06Z","timestamp":1782348006941,"version":"3.54.5"},"reference-count":13,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>Bolesatine is a toxic glycoprotein isolated from Boletus satanas Lenz, which inhibits protein synthesis in vivo and in vitro. The LD50 (24 h) is 1 mg \/kg bw (i.p.), in mice and rats. When given i.p. to mice (0.1 - 1.0 mg\/kg bw) bolesatine induced thrombi and blood stasis in the liver, 5 - 21 h after injection, and modifications of the number of blood corpuscles in peripheral blood. These effects were efficiently reversed by aspirin, ticlopidin and heparin (as attested by histology and electron microscopy) which however failed to prevent death in animals given lethal doses. Together, these results showed that the death of bolesatine poisoned animals given high doses, was rather due to a combination of thrombosis and other toxic effects. In addition, they suggest that these antithrombotic drugs may overcome cases of human poisoning, with low exposures of this boletus, showing a hypertension probably due to mechanical obstruction which resists normal therapy.<\/jats:p>","DOI":"10.1177\/096032719801701106","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T14:52:48Z","timestamp":1484664768000},"page":"620-624","source":"Crossref","is-referenced-by-count":4,"title":["Aspirin\u00ae and heparin prevent hepatic blood stasis and thrombosis                 induced by the toxic glycoprotein Bolesatine in mice"],"prefix":"10.1177","volume":"17","author":[{"given":"R","family":"Ennamany","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bordeaux II, Unit\u00e9 de Formation et de                         Recherche des Sciences Pharmaceutiques, 146, rue L\u00e9o Saignat                         33076 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bingen","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherches INSERM U 74 et Institut de Virologie de la                         Facult\u00e9deM\u00e9decinedel'Universit\u00e9 Louis                         Pasteur, 67000 Strasbourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E E","family":"Creppy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux II, Unit\u00e9 de Formation et de                         Recherche des Sciences Pharmaceutiques, 146, rue L\u00e9o Saignat                         33076 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Kretz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux II, Unit\u00e9 de Formation et de                         Recherche des Sciences Pharmaceutiques, 146, rue L\u00e9o Saignat                         33076 Bordeaux"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Gut","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherches INSERM U 74 et Institut de Virologie de la                         Facult\u00e9deM\u00e9decinedel'Universit\u00e9 Louis                         Pasteur, 67000 Strasbourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Dubuisson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux II, Laboratoire des Interactions                         cellulaires, 146, rue L\u00e9o Saignat 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Balabaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux II, Laboratoire des Interactions                         cellulaires, 146, rue L\u00e9o Saignat 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Bioulac","family":"Sage","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux II, Laboratoire des Interactions                         cellulaires, 146, rue L\u00e9o Saignat 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kirn","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherches INSERM U 74 et Institut de Virologie de la                         Facult\u00e9deM\u00e9decinedel'Universit\u00e9 Louis                         Pasteur, 67000 Strasbourg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74117-3_83"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(91)90220-U"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(92)90071-L"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/096032719601500105"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(93)90366-M"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.3109\/00498259109039451"},{"key":"atypb7","unstructured":"Kretz, O. Isolementet\u00e9tude des propri\u00e9t\u00e9s                 Physico-chimiques, Biologiques et Toxicologiques de la bol\u00e9satine, toxine                 glycoprot\u00e9ique extraite de Boletus satanas Lenz.                 Th\u00e9sedel'Universit\u00e9Louis Pasteur de Strasbourg. Option                 Toxicologie 1992."},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(94)90219-4"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050223"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03058-N"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/BF01305906"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03113-T"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032719801701106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096032719801701106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:00Z","timestamp":1777448760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096032719801701106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1998,11]]}},"alternative-id":["10.1177\/096032719801701106"],"URL":"https:\/\/doi.org\/10.1177\/096032719801701106","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,11]]}}}