{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:05Z","timestamp":1777928165829,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p>Serious infection is a common problem in immunosuppressed patients with systemic lupus erythematosus (SLE). Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei and may present as an acute fulminant pneumonia or septicaemia that is often fatal. The organism is endemic in much of South-east Asia but is being increasingly reported from other parts of the world, including India, Northern Australia and North and South America. In addition to occurring in people who come into contact with contaminated soil or water in endemic areas, the infection is more common in immunosuppressed patients and must be recognised early and treated with appropriate antibiotics. Importantly, it can activate many years after the initial exposure, causing diagnostic confusion. We present the cases of three patients with SLE who were admitted with fever and in whom Burkholderia pseudomallei was isolated from blood cultures. Following treatment with intravenous ceftazidime all patients made a good recovery. These cases demonstrate the importance of considering this infectious organism in patients from endemic areas with unexplained fever. They also illustrate how successful outcomes can be achieved in a frequently fatal disease if an early diagnosis is made and appropriate antibiotics are started promptly.<\/jats:p>","DOI":"10.1177\/096120330101001111","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T22:11:54Z","timestamp":1162505514000},"page":"821-823","source":"Crossref","is-referenced-by-count":4,"title":["Melioidosis in systemic lupus erythematosus: the importance of early                 diagnosis and treatment in patients from endemic areas"],"prefix":"10.1177","volume":"10","author":[{"given":"H","family":"Badsha","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Allergy and Immunology, Tan TockSeng                         Hospital, 11, Jalan Tan TockSeng, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H H","family":"Chng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Immunology, Tan TockSeng                         Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(99)00059-5"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1086\/520223"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90768-X"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.5.1420"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400030135027"},{"key":"atypb6","first-page":"249","volume":"53","author":"Walsh AL","year":"1996","journal-title":"Br J Biomed Sci"},{"key":"atypb7","first-page":"119","volume":"46","author":"ZyskG","year":"2000","journal-title":"Clin Lab"},{"key":"atypb8","first-page":"406","volume":"34","author":"Oh HM","year":"1993","journal-title":"Singapore Med J"},{"key":"atypb9","first-page":"347","volume":"78","author":"Christenson-Bravo B","year":"1986","journal-title":"Bol Assoc Med P R"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.5.650"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2000.00179.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(99)00062-5"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.5.1181"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096120330101001111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096120330101001111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:55Z","timestamp":1777676755000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096120330101001111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1177\/096120330101001111"],"URL":"https:\/\/doi.org\/10.1177\/096120330101001111","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}