{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:19Z","timestamp":1777928179269,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>The objectives of the study were to characterize the production, function and survival of T lymphocytes of children with prolonged fetal exposure to dexamethasone for anti-Ro\/SS-A antibodies associated congenital complete heart block. The analysis of thymic function, studied by measuring the level of T-cell receptor excision circles, was performed by real time PCR, the composition of T-cell subpopulation was evaluated by flow cytometry and the T-cell diversity was assayed by heteroduplex analysis. T-cell competence was gauged at two functional levels by determining the proliferation and the number of T-cell divisions and by measuring \u03b3-interferon production after mitogenic stimulation. We observed that the thymic output, distribution of T-cell subsets, thymidine incorporation, number of T-cell divisions, and \u03b3-interferon production were comparable to those of age-matched control. On the contrary, heteroduplex analysis demonstrated the presence of both polyclonal and oligoclonal peripheral T-cell repertoires.<\/jats:p>\n                  <jats:p>In conclusion, the analysis of the T-cell compartment in children with prolonged intrauterine exposure to high dose dexamethasone did not disclose any relevant abnormality, except a restriction of T-cell receptor diversity in some patients.<\/jats:p>","DOI":"10.1177\/0961203306071869","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T16:12:45Z","timestamp":1162829565000},"page":"553-561","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of T-cell population in children with prolonged fetal                 exposure to dexamethasone for anti-Ro\/SS-A antibodies associated congenital heart block"],"prefix":"10.1177","volume":"15","author":[{"given":"P","family":"Air\u00f3","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology, Spedali 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