{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:37Z","timestamp":1777928197800,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>To evaluate cervicovaginal cytology in adolescents with juvenile systemic lupus erythematosus (JSLE) and to compare them to controls. Fifty-two female adolescents with JSLE (ACR criteria) were compared to 52 age-matched healthy controls. All Pap smears were evaluated by the same cytopathologist blinded to gynecology examination (Bethesda 2001). The mean age of JSLE patients and controls were similar (16.17 \u00b1 1.94 versus 16.13 \u00b1 2.16 years, P = 0.92). The cervicovaginal cytology was found to be similar in both groups, although sexual intercourses in the last month were less frequent in JSLE than controls (23% versus 59.6%, P = 0.0003). Only one patient (2%) with JSLE versus two controls (4%) had cervical dysplasia (LGSIL) and human papilomavirus ( P = 1.0). Candida spp vaginitis was observed in seven JSLE (14%) versus none in controls ( P = 0.012) and was associated with immunosuppressive drugs ( P = 0.01) and high dose of prednisone ( P = 0.002). Of interest, inflammatory cervicovaginal cytology was observed in 21 (60%) of patients with SLEDAI \u2265 4 and only four (23%) of those with SLEDAI &lt; 4 ( P = 0.001). Likewise, a higher frequency of inflammatory changes was also observed in virgin JSLE (57% versus 8%, P = 0.005). Our findings supports the notion that female genital tract may be a potential target organ in SLE since cervical inflammation is associated to disease activity independently of sexual activity. Lupus (2007) 16, 430\u2014435.<\/jats:p>","DOI":"10.1177\/0961203307079298","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T07:18:42Z","timestamp":1185779922000},"page":"430-435","source":"Crossref","is-referenced-by-count":31,"title":["Inflammatory cervicovaginal cytology is associated with disease activity in juvenile systemic lupus erythematosus"],"prefix":"10.1177","volume":"16","author":[{"given":"M.V.","family":"Febronio","sequence":"first","affiliation":[{"name":"Rheumatology Division; Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Rheumatology Division; Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bonfa","sequence":"additional","affiliation":[{"name":"Rheumatology Division; Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Takiuti","sequence":"additional","affiliation":[{"name":"Gynecology Division, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.G.","family":"Pereyra","sequence":"additional","affiliation":[{"name":"Gynecology Division, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil, clovisaas @icr.hcnet.usp.br"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2005.01.010"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199909000-00010"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000137852.42270.0f"},{"key":"atypb4","doi-asserted-by":"crossref","unstructured":"Aagaard-Tillery KM, Holmgren CM, Scott JR Gynecologic problems in women with autoimmune diseases. In Lockshin M, Branch DW eds. Handbook of systemic autoimune diseases, Vol. 4. Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases, 1st edition. Elsevier , 2006: 141\u2014160.","DOI":"10.1016\/S1571-5078(05)04012-2"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000160897.74492.a3"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.3.335"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/096120339400300112"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240503"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6207"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/art.20616"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.02.006"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/096120330000900711"},{"key":"atypb13","first-page":"1763","volume":"31","author":"Ognenovski VM","year":"2004","journal-title":"J Rheumatol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh331"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"atypb16","unstructured":"Almeida PM, Wickerrhauser H. Crit\u00e9rio de classe econ\u00f4mica da Associa\u00e7\u00e3o Brasileira de Anunciantes (ABA) e Associa\u00e7\u00e3o Brasileira dos Institutos de Pesquisa de Mercado (ABIPEME), 1991: 1\u201429."},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1354::AID-ANR8>3.0.CO;2-4"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/art.10072"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(93)90248-B"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(02)00022-2"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92299-3"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1136\/sti.74.1.11"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198709000-00002"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.03.005"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1086\/380466"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000165822.29451.54"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1007\/s004040050228"},{"key":"atypb30","first-page":"37","volume":"51","author":"Prussia PR","year":"2002","journal-title":"West Indian Med J"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1159\/000326721"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu219oa"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.539"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2004.10.005"},{"key":"atypb35","unstructured":"Hillard Pja. Pediatric and adolescent gynecology. In Scott JR, Saia PJ, Hammond CB, Spellacy WN eds. Danforth's obstetrics & gynecology, 9th edition. Lippincott Williams & Wilkins, 1999: 529\u2014540."},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053284"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203307079298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203307079298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:06:48Z","timestamp":1777676808000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203307079298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/0961203307079298"],"URL":"https:\/\/doi.org\/10.1177\/0961203307079298","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}