{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:07:36Z","timestamp":1792735656270,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Autoantibodies against dense fine speckles 70 (DFS70) are found in 10% of healthy individuals, but only in a tiny population of patients with autoimmune rheumatic disease. The antibody may thus be a marker of autoimmune rheumatic disease negativity. To investigate this possibility, we examined the presence of various disease-marker autoantibodies in anti-DFS70 antibody\u2013positive patients with autoimmune rheumatic disease. Serum samples from 500 patients with various types of autoimmune rheumatic disease were examined for anti-DFS70 antibodies by indirect immunofluorescence and immunoblotting. Various disease-marker autoantibodies were measured by enzyme-linked immunosorbent assay. Twenty-two patients were positive for anti-DFS70 antibodies. Eighteen patients also had disease-marker autoantibodies including anti\u2013double stranded DNA, anti-cardiolipin, anti-SS-A, or other antibodies. In one patient with Sj\u00f6gren syndrome and two patients with dermatomyositis, no disease-marker antibodies were found; however, one patient with dermatomyositis had a concomitant anti-cytoplasmic antibody. All seven systemic lupus erythematosus patients fulfilled the classification criteria for this disease even if anti-nuclear antibody\u2013positive findings were excluded. One patient with morphea had high-titer anti\u2013single stranded DNA antibody. According to this and previous studies, patients with only anti-DFS70 antibody are rarely diagnosed as having autoimmune rheumatic disease. Recognizing dense fine speckle patterns in anti-nuclear antibodies tests is, thus, very important for analysis of laboratory results in rheumatology clinics.<\/jats:p>","DOI":"10.1177\/0961203307086311","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T11:03:38Z","timestamp":1206615818000},"page":"171-176","source":"Crossref","is-referenced-by-count":85,"title":["High concomitance of disease marker autoantibodies in anti-DFS70\/LEDGF                 autoantibody\u2013positive patients with autoimmune rheumatic disease"],"prefix":"10.1177","volume":"17","author":[{"given":"Y","family":"Muro","sequence":"first","affiliation":[{"name":"Division of Connective Tissue Disease & Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Division of 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