{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:57:00Z","timestamp":1777928220903,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>We hypothesized that nucleic acids, free and\/or complexed, filtered and\/or locally released, might be entrapped in the kidneys because of the specific nucleic acid binding microbial pattern recognizing Toll-like receptors (TLRs). This hypothesis of nucleic acid binding potential was tested using paraffin sections from healthy control, SLE and transplant kidneys, which were labelled using TLR-specific rabbit or goat anti\u2013human antibodies in immunoperoxidase staining. Normal and transplant kidneys contain some double- (TLR-3) and single-stranded RNA binding (TLR-8) receptors, but in particular double-stranded RNA binding receptor TLR-7, mostly in tubuli, whereas no DNA binding TLR-9 was found. SLE kidneys contain more TLR-3 and TLR-8 and express de novo also TLR-9, in particular in glomeruli. On the contrary, TLR-7 was relatively weak in SLE. It is concluded that kidneys have a capacity to bind nucleic acids. TLR stimulation leads to the production of tumour necrosis factor-\u03b1 and other pro-inflammatory cytokines and to up-regulation of co-stimulatory molecules necessary for the adaptive immune response. This makes renal tissues a potential target for inflammatory and immune responses in autoimmune disease and in the reaction for the foreign tissue.<\/jats:p>","DOI":"10.1177\/0961203307088130","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T11:34:16Z","timestamp":1212752056000},"page":"580-585","source":"Crossref","is-referenced-by-count":13,"title":["Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys \u2013 a preliminary pilot study"],"prefix":"10.1177","volume":"17","author":[{"given":"H","family":"Ciferska","sequence":"first","affiliation":[{"name":"III. Department of Internal Medicine, Faculty of Medicine and Faculty Hospital, University of Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Horak","sequence":"additional","affiliation":[{"name":"III. 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