{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:57:22Z","timestamp":1777928242846,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>The role of tumour necrosis factor (TNF-\u03b1) signalling adapters in lupus nephritis (LN) is poorly understood. This study investigated renal expression of TNF-\u03b1 and TNF signalling adapter proteins, including TNF receptor-associated death domain protein (TRADD), receptor-interacting protein (RIP) and TNF receptor-associated factor-2 (TRAF-2) in patients with LN. The renal expression of proliferating cell nuclear antigen (PCNA) and CD68 was also measured. The study showed that glomerular and tubular expression of TNF-\u03b1, TRADD, RIP and TRAF-2 was significantly up-regulated in class III and IV LN in which the intense staining was observed on the crescents, proximal and distal tubules and interstitial mononuclear cells. The number of PCNA-positive cells and CD68-positive cells (macrophages) was increased obviously in class III and IV LN. There was a correlation between the expression levels of TNF-\u03b1, TRADD, RIP, TRAF-2 and the number of PCNA-positive or CD68-positive cells and active index of renal pathology. These findings suggest that TNF-\u03b1 and TNF-\u03b1 adapters in patients with LN play a role in immunopathogenic injury via transmitting abnormal cell proliferating and proinflammatory signals. The findings have provided further insights into the role of TNF-\u03b1 and its adapter proteins in the pathogenesis of LN and have important therapeutic implications.<\/jats:p>","DOI":"10.1177\/0961203308094764","type":"journal-article","created":{"date-parts":[[2009,1,16]],"date-time":"2009-01-16T10:00:00Z","timestamp":1232100000000},"page":"116-127","source":"Crossref","is-referenced-by-count":33,"title":["Up-regulated renal expression of TNF-\u03b1 signalling adapter proteins in lupus glomerulonephritis"],"prefix":"10.1177","volume":"18","author":[{"given":"L","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SF","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60279-7"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.14"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2006.09.005"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2005.09.002"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2056oa"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1681\/ASN.V102413","volume":"10","author":"Cameron JS","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.02.004"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2053oa"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.11.1067"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191429"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678919949"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1186\/ar770"},{"key":"atypb13","first-page":"CD002922","author":"Flanc RS","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu1024oa"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00019-9"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00237-9"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01007.x"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0531-8"},{"key":"atypb19","first-page":"4282","volume":"58","author":"Li ZR","year":"1998","journal-title":"Cancer Res"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.12.971"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199410000-00004"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.01.009"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200512"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00443.x"},{"key":"atypb28","unstructured":"28 Pirani C\u2004. L. S-M, Koss, M. Evaluation of renal biopsy. In: Sommers, C, (ed), Pathology Decennial\u2004, (1965\u20131975). 1st ed. New York: Appleton Century Crofts; 1975, 109\u2013163."},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.75"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02064-5"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172382999"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90253-8"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90070-5"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80984-8"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80252-6"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90071-3"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81375-6"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1038\/32681"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.61.5.559"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90149-3"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388205"},{"key":"atypb42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1242\/jcs.96.1.121","volume":"96","author":"Waseem NH","year":"1990","journal-title":"J Cell Sci"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910590315"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80312-X"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203308094764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203308094764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:07:51Z","timestamp":1777676871000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203308094764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1177\/0961203308094764"],"URL":"https:\/\/doi.org\/10.1177\/0961203308094764","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}