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In this case, we present the time trends of platelet count and volume and the histopathology of the kidney of a patient with systemic lupus erythematosus and a mutation in the Wiskott-Aldrich syndrome gene. The patient suffered from congenital recessive X-linked thrombocytopenia, and he developed systemic lupus erythematosus at the age of 12\u00a0years. Thus, his disease was reclassified as Wiskott-Aldrich syndrome, class 5. The g.257G\u00a0&gt;\u00a0A mutation in the Wiskott-Aldrich syndrome gene and reduced expression of the specific messenger were revealed by molecular analyses.<\/jats:p>","DOI":"10.1177\/0961203308095000","type":"journal-article","created":{"date-parts":[[2009,2,12]],"date-time":"2009-02-12T11:18:34Z","timestamp":1234437514000},"page":"273-277","source":"Crossref","is-referenced-by-count":14,"title":["Systemic lupus erythematosus and Wiskott-Aldrich syndrome in an Italian patient"],"prefix":"10.1177","volume":"18","author":[{"given":"G","family":"Monteferrante","sequence":"first","affiliation":[{"name":"Department of Nephrology, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Giani","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Ospedale Policlinico Maggiore, Fondazione-Mangiagalli e IRCCS Regina Elena, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"1 Derry JM; \u2004Ochs HD; \u2004Francke U; \u2004. 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