{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:47:57Z","timestamp":1791204477501,"version":"4.2.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>The role of autoantibodies in the pathogenesis of systemic lupus erythematosus (SLE) has not been completely defined. From more than a hundred autoantibodies described in SLE, relatively few have been associated with clinical manifestations. The glycan-binding proteins of the galectin family can modulate the immune system. Anti-galectin autoantibodies thus could have functional and\/or pathogenic implications in inflammatory processes and autoimmunity. We previously reported function-blocking autoantibodies against galectin-8 (Gal-8) in SLE. Here we tested these autoantibodies against a series of other human galectins and demonstrated their specificity for Gal-8, being detectable in 23% of 78 SLE patients. Remarkably, they associated with lymphopenia (50% of 18 anti-Gal-8-positive versus 18% of 60 anti-Gal-8-negative cases, Fisher\u2019s Exact test two-tailed: P\u00a0&lt;\u00a00.012). Lymphopenia is a common clinical manifestation in SLE, yet of unknown mechanism. In addition, six of eight patients with both lymphopenia and malar rash had anti-Gal-8 in their sera. Occurrence of these autoantibodies was not confined to SLE as we also found them in sera of patients with rheumatoid arthritis (16%) and septicemia (20%). This study thus establishes occurrence of specific anti-Gal-8 autoantibodies in autoimmune rheumatic diseases and in acute inflammation, with an apparent association to a clinical subset in SLE.<\/jats:p>","DOI":"10.1177\/0961203308099973","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T09:42:42Z","timestamp":1240566162000},"page":"539-546","source":"Crossref","is-referenced-by-count":47,"title":["Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation"],"prefix":"10.1177","volume":"18","author":[{"given":"L","family":"Massardo","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda Cl\u00ednica y Reumatolog\u00eda, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Metz","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda Cl\u00ednica y Reumatolog\u00eda, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile; 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