{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:57:42Z","timestamp":1777928262763,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T00:00:00Z","timestamp":1246579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    We present long-term outcomes of BXSB mice after non-myeloablative bone marrow transplants using major histocompatability complex (MHC)-matched cells. Groups differed in sources of donor lymphocytes or mesenchymal stromal cells (MSC). Unfractionated marrow cells from green fluorescent protein (GFP) transgenic (Tg) mice (BMT group) or from RAG1\u2212\/\u2212 B6 mice (RAG group) were injected intravenously (i.v.) into irradiated (550 cGy) hosts. As a source of mesenchymal cells, bone chips from GFP-Tg were injected intraperitoneally alone (MSC group) or along with i.v. bone marrow cells (BMT\u00a0+\u00a0MSC group). Controls were untreated mice (UnTx) or mice exposed to radiation only (Rad Cont). At 62\u00a0weeks post-transplant, surviving mice were harvested for histopathology, flow cytometry and real time polymerase chain reaction (RT-PCR). The mice from BMT\u00a0+\u00a0MSC group had the best outcomes for survival rates (71.4% vs. 43.8%), renal scores (2.9% vs. 28.8% glomerular sclerosis) and percent splenic monocytes (4.2 vs. 11.3%) compared with mice from Rad Cont. Improvement in RAG and BMT groups was less prominent but were comparable with one another. Although MSC alone were not sufficient to control the renal pathology, it limited the expansion of CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD8\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cell populations without a change in Foxp3 expression. The results suggest the importance of the innate immune system in disease pathogenesis and a role for MSC in immunomodulation.\n                  <\/jats:p>","DOI":"10.1177\/0961203309104391","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T09:38:26Z","timestamp":1246613906000},"page":"813-821","source":"Crossref","is-referenced-by-count":2,"title":["Long-term follow-up after non-myeloablative transplant of bone and marrow in BXSB mice"],"prefix":"10.1177","volume":"18","author":[{"given":"OY","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Walter Reed Army Medical Center, Georgia Avenue, NW, Washington  DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lacson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Mackenzie Health Sciences Centre. Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Zeng","sequence":"additional","affiliation":[{"name":"R&D, SABiosciences Corporation, Executive Way, Frederick, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Jones","sequence":"additional","affiliation":[{"name":"Immunology Consultant, Potomac, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Katti","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RA","family":"Cahill","sequence":"additional","affiliation":[{"name":"Cardinal Glennon Hospital, South Grand Avenue, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AA","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Mercy 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