{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:57:46Z","timestamp":1777928266652,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>We report a patient with Down syndrome, under treatment with carbamazepine, levopromazine and clonazepam. After urinary infection he developed glans necrosis requiring excision of prepuce. Six hours post surgery he presented right-hand ischemia followed by arterial and venous thrombosis of the right thoracic extremity. Later, he progressed to a compartment syndrome and presented ischemia of toes. All the clinical manifestations developed over a week. Anticardiolipin (aCL) antibodies, lupus anticoagulant and perinuclear antineutrophil antibodies were positive. Anticoagulant and immunosuppressive treatment were initiated. Owing to the failure of both treatments, the patient underwent amputation of right hand and a toe. Histopathology revealed recent and old thrombosis of medium- and small-sized vessels without vasculitis. Diagnosis of catastrophic antiphospholipid syndrome (CAPS) was made. At present, the patient continues on oral anticoagulants, IgG aCL remains positive, and no further episodes of thromboses have been observed after 4\u00a0years of follow-up. To our knowledge, this is the first case of CAPS in a patient with Down syndrome.<\/jats:p>","DOI":"10.1177\/0961203309105878","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T06:08:29Z","timestamp":1253167709000},"page":"1104-1107","source":"Crossref","is-referenced-by-count":6,"title":["Catastrophic antiphospholipid syndrome in a patient with Down syndrome"],"prefix":"10.1177","volume":"18","author":[{"given":"Gabriela","family":"Medina","sequence":"first","affiliation":[{"name":"Clinical Research Unit, Hospital de Especialidades Centro M\u00e9dico La Raza, IMSS, Mexico City, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Calleja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital de Especialidades Centro M\u00e9dico La Raza, IMSS, M\u00e9xico City, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massiel","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Medical Student, Universidad Aut\u00f3noma de Nayarit, Tepic, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Vera-Lastra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital de Especialidades Centro M\u00e9dico La Raza, IMSS, M\u00e9xico City, M\u00e9xico; Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis J","family":"Jara","sequence":"additional","affiliation":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City, M\u00e9xico; Direction of Education and Research, Hospital de Especialidades Centro M\u00e9dico La Raza, IMSS, M\u00e9xico City, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S1571-5078(07)00211-5"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1994.tb04170.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu240cr"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.056"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200210000-00018"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.06.005"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.10.013"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2001.27660"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e318183136d"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.6.771"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu394oa"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/art.22018"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.06.009"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.4.868"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0127-8"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.05.004"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203309105878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203309105878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:08:33Z","timestamp":1777676913000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203309105878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,17]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1177\/0961203309105878"],"URL":"https:\/\/doi.org\/10.1177\/0961203309105878","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,17]]}}}