{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:17:56Z","timestamp":1787987876315,"version":"build-2784847793"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>This study is to assess the difference between IV-G and IV-S in a large cohort of Chinese patients with lupus nephritis. The detailed data of patients with subclass IV-G and IV-S were retrospectively analyzed. Serum ANCA and anti-C1q antibodies were detected. A total of 172 cases were classified as class IV, including 152 cases with IV-G and 20 cases with IV-S. In IV-S, the level of haemoglobin was significantly higher ( P\u00a0=\u00a00.024), proteinuria was milder ( P\u00a0=\u00a00.003), serum creatinine was lower ( P\u00a0=\u00a00.021), serum C3 was higher ( P\u00a0=\u00a00.045) and the ratio of positive serum anti-cardiolipin antibodies was higher ( P\u00a0=\u00a00.014). On pathological evaluation, the ratio of glomerular fibrinoid necrosis was significantly higher ( P\u00a0=\u00a00.006) and the score of endocapillary hypercellualrity, interstitial inflammation and total activity indices was significantly lower ( P\u00a0&lt;\u00a00.001, P\u00a0=\u00a00.01, P\u00a0=\u00a00.006, respectively) in IV-S. The frequency of serum ANCA was significantly higher in IV-S than that in IV-G (20 vs 4.6%, P\u00a0=\u00a00.008). The frequencies of anti-C1q IgG1 and IgG3 subclass were significantly higher in IV-G ( P\u00a0=\u00a00.006, P\u00a0=\u00a00.011, respectively). There are significant differences in clinical and pathological manifestations between IV-S and IV-G lupus nephritis which need further investigation.<\/jats:p>","DOI":"10.1177\/0961203309106795","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T06:08:29Z","timestamp":1253167709000},"page":"1073-1081","source":"Crossref","is-referenced-by-count":30,"title":["Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center"],"prefix":"10.1177","volume":"18","author":[{"given":"F","family":"Yu","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key laboratory of Renal Disease, Ministry of Health of China, Beijing 100034 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tan","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key laboratory of Renal Disease, Ministry of Health of China, Beijing 100034 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-H","family":"Wu","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key laboratory of Renal Disease, Ministry of Health of China, Beijing 100034 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-N","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Peking University First Hospital, Beijing 100034, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Liu","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key laboratory of Renal Disease, Ministry of Health of China, Beijing 100034 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-H","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key laboratory of Renal Disease, Ministry of Health of China, Beijing 100034 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"atypb1","unstructured":"1 Appel GB\u2004 Radhakrishnan J\u2004 D'Agati VD\u2004. 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