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The diagnosis of systemic lupus erythematosus and Sj\u00f6gren\u2019s syndrome was made and treatment with glucocorticoid pulse followed by oral glucocorticoid was started. It is highly probable that interferon-\u03b1-induced systemic lupus erythematosus and Sj\u00f6gren\u2019s syndrome in this case. Interferon-\u03b1 might be important pathogenically in these diseases. 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