{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:58:18Z","timestamp":1777928298883,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T00:00:00Z","timestamp":1269907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n                    Since \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -glycoprotein I (\u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI) was described as the major antigenic target for antiphospholipid antibodies, many studies have focused their attention to the physiological role of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI and anti-\u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI antibodies on autoimmune-mediated thrombosis. Studies reporting the physiological role of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI have been numerous, but the exact mechanism of action(s) has yet to be completely determined. \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI\u2019s epitopes for anti-\u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI autoantibodies have been characterized, however, not all of the heterogeneous anti-\u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI antibodies are pathogenic. The pathophysiologic role of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI has been reported in the fields of coagulation, fibrinolysis, angiogenesis, and atherosclerosis. Our understanding of the impact of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI, its metabolites and autoantibodies to \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    GPI on these physiological functions may contribute to the development of better therapeutic strategies to treat and prevent autoimmune-mediated atherothrombotic vascular disease. Lupus (2010) 19, 379\u2014384.\n                  <\/jats:p>","DOI":"10.1177\/0961203310361352","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T10:04:36Z","timestamp":1269943476000},"page":"379-384","source":"Crossref","is-referenced-by-count":26,"title":["Pathophysiology of \u03b22-glycoprotein I in antiphospholipid syndrome"],"prefix":"10.1177","volume":"19","author":[{"given":"E.","family":"Matsuura","sequence":"first","affiliation":[{"name":"Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Matsunami","sequence":"additional","affiliation":[{"name":"Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Makarova","sequence":"additional","affiliation":[{"name":"Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FJ","family":"Geske","sequence":"additional","affiliation":[{"name":"Corgenix Inc, Broomfield, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Boisen","sequence":"additional","affiliation":[{"name":"Corgenix Inc, Broomfield, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Medicine , Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LR","family":"Lopez","sequence":"additional","affiliation":[{"name":"Corgenix Inc, Broomfield, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.19.5166"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.22.6228"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.d01-948.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200329-JLR200"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01161.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90237-0"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653871"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657748"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2004.00649.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650220"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010990200"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90163-7"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648517"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2006.05.001"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649577"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119401"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.7.2426.2426"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199901)42:1<167::AID-ANR20>3.0.CO;2-B"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614977"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90915-1"},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.4049\/jimmunol.153.3.1328","volume":"153","author":"Kornberg A.","year":"1994","journal-title":"J Immunol"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02180.x"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212655200"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2349"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2141"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.11.4173"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.8.1183"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614424"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2712"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49853-0"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1038\/nm0195-27"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.46.29461"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10868"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2141"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2712"},{"key":"atypb37","first-page":"486","volume":"13","author":"Hughes GR","year":"1986","journal-title":"J Rheumatol"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.2.457"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.12.1247"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.8.1701"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1002\/art.20780"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1002\/art.10187"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.02.016"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.17.2227"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200329-JLR200"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.073"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP2FJUT2YZGITK"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100008"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.07.003"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307084170"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310361352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310361352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:09:23Z","timestamp":1777676963000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203310361352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,30]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1177\/0961203310361352"],"URL":"https:\/\/doi.org\/10.1177\/0961203310361352","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,30]]}}}