{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:46:40Z","timestamp":1792788400318,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T00:00:00Z","timestamp":1270598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>An inception cohort of patients with systemic lupus erythematosus from 14 European centres was followed for up to 5 years in order to describe the current early disease course. At inclusion patients (n = 200, 89% female, mean age 35 years, 97% Caucasian, mean SLEDAI 12.2) fulfilled a mean of 6.5 ACR classification criteria. The most prevalent criteria were antinuclear Ab presence (97%) followed by anti-dsDNA Ab (74%), arthritis (69%), leukocytopenia (54%) and malar rash (53%), antiphospholipid Ab (48%) and anti-synovial membrane Ab (21.6%). Clinical signs of lupus nephritis (LN) were present in 39% with biopsy-confirmed LN seen in 25%. Frequent additional findings were hypocomplementaemia (54%), anti-SSA Ab (49%), alopecia (26%) and Raynaud\u2019s phenomenon (31%). There were few regional differences in disease presentation and management. One and 5-year survival rates were 99% and 97% respectively. During the mean follow-up of 4.1 years 25% entered a state of early disease quiescence by global physician assessment, but the overall risk of subsequent flare was 60%. Maximum SLEDAI scores decreased over time, but 45% of patients accrued damage (SDI \u22651) for which baseline presence of proteinuria and persistent disease activity were independent predictors. The results indicate minor differences in SLE presentation and treatment within various regions of Europe and a high diagnostic reliance on anti-dsDNA Ab. Despite early reductions in disease activity and improved mortality, the risk for disease flare and damage development is, however, still substantial, especially in patients not entering an early remission.<\/jats:p>","DOI":"10.1177\/0961203310366572","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T21:09:06Z","timestamp":1270674546000},"page":"949-956","source":"Crossref","is-referenced-by-count":142,"title":["Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus"],"prefix":"10.1177","volume":"19","author":[{"given":"J.","family":"Nossent","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Institute of Clinical Medicine, University of Troms\u00f8, Troms\u00f8, Norway,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Rozman","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Dr Peter Drzaj Hospital, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pokorny","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Szent-Gyorgyi Medical University Centre, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vlachoyiannopoulos","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Olesinska","sequence":"additional","affiliation":[{"name":"Department of Connective Tissue Diseases, Institute of Rheumatology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marchesoni","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Istituto Ortopedico Gaetano Pini, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mosca","sequence":"additional","affiliation":[{"name":"Universita degli Studi di Pisa, Dipartimenti di Medicina Interna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"P\u00e5i","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Manger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute for Clinical Immunology, University of Erlangen-Nurnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medical Clinic, Department of Rheumatology, Heinrich-Heine University, Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Herlev Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van Vollenhoven","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Swaak","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ikazia Ziekenhuis, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4,7]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90431-9"},{"key":"atypb2","unstructured":"Gladman DD, Urowitz MB Prognosis, mortality, and morbidity in systemic lupus erythematosus. 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