{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:58:32Z","timestamp":1777928312534,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T00:00:00Z","timestamp":1279584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Increased levels of serum prolactin have been reported in patients with various autoimmune diseases and have been associated with lupus disease activity. Currently, there is a lack of data regarding hyperprolactinaemia in patients with the antiphospholipid syndrome. Hence, this study was carried out in order to evaluate the prevalence and clinical significance of hyperprolactinaemia in antiphospholipid syndrome. A total of 172 European patients with antiphospholipid syndrome and 100 geographically and sex-matched healthy controls were included in the study; none had obvious causes of hyperprolactinaemia. All patients underwent clinical assessment for disease manifestations, in addition to laboratory assessment for serum prolactin, antiphospholipid antibodies and some other biomarkers of autoimmune diseases. The tests were performed utilizing the LIAISON\u00ae Analyzer (DiaSorin, Sallugia Italy). Hyperprolactinaemia was detected in 21\/172 patients with antiphospholipid syndrome and 0\/100 controls (p &lt; 0.001). This significant difference was present in both genders and was obvious even after subgrouping the patients into primary and secondary antiphospholipid syndrome. When clinical features were compared, hyperprolactinaemia was associated with reproductive failure, including early and late pregnancy loss (p &lt; 0.05), as well as intrauterine growth retardation (p &lt; 0.05). Hyperprolactinaemia was negatively related to arthralgias, venous thrombosis, pulmonary microthrombosis, pulmonary hypertension in both primary antiphospholipid syndrome and antiphospholipid syndrome secondary to other diseases, and to neurological manifestations in primary antiphospholipid syndrome (p&lt;0.05). The data indirectly imply that prolactin may play a role in the pathogenesis of antiphospholipid syndrome, especially antiphospholipid syndrome-related reproductive failure.<\/jats:p>","DOI":"10.1177\/0961203310373781","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T20:41:47Z","timestamp":1279658507000},"page":"1515-1519","source":"Crossref","is-referenced-by-count":33,"title":["Prolactin\u2019s role in the pathogenesis of the antiphospholipid syndrome"],"prefix":"10.1177","volume":"19","author":[{"given":"S.","family":"Praprotnik","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Clinical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Agmon-Levin","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel-Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BS","family":"Porat-Katz","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Blank","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel-Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PL","family":"Meroni","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine-University of Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cervera","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases, Hospital Cl\u00ednic, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Miesbach","sequence":"additional","affiliation":[{"name":"Medical Clinic , Institute of Transfusion Medicine, University Hospital, Johann Wolfgang Goethe-University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Stojanovich","sequence":"additional","affiliation":[{"name":"Bezhanijska Kosa University Medical Center, Beograd, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Szyper-Kravitz","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel-Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rozman","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Clinical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tomsic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Clinical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel-Aviv Israel, Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,20]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.10.005"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2004.04.007"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/art.24500"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920316"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07629.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-005-5082-5"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei115"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10420"},{"key":"atypb9","first-page":"629","volume":"23","author":"Buskila D.","year":"1996","journal-title":"J Rheumatol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.05.014"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1995.1058"},{"key":"atypb12","first-page":"2084","volume":"22","author":"McMurray RW","year":"1995","journal-title":"J Rheumatol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920334"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082267"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-7-17"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-825727"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39479"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-12-0801"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081194"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.024"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8146-x"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.021444"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8576"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082768dh"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310373781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310373781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:09:44Z","timestamp":1777676984000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203310373781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,20]]},"references-count":24,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1177\/0961203310373781"],"URL":"https:\/\/doi.org\/10.1177\/0961203310373781","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,20]]}}}