{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:58:37Z","timestamp":1777928317673,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:00:00Z","timestamp":1280188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Mixed connective tissue disease (MCTD) is a rare disease that includes clinical and laboratorial manifestations of systemic lupus erythematosus, scleroderma and polymyositis that is associated with high titers of anti-U1RNP antibodies. In general, muscle involvement is subclinical, usually appearing as an increase in muscle enzyme levels that tends to be a characteristic of the initial phases of the disease. Severe clinical muscle weakness is not observed in this disease. The objective of this study is to report a rare case of a patient who presented a severe onset of myositis characterized by dysphagia, an increase in myopathy and a weakening of the cervical musculature. While there was no response to the administration of an initial dose of corticosteroids, improvement was observed after increasing the dose of corticosteroids, in addition to the initiation of pulse therapy with methylprednisolone accompanied by methotrexate treatment. The authors emphasize that there is only one previously reported case regarding a child with MCTD and severe clinical myopathy on electromyography and muscle biopsy, and they report in this article one adult female patient who presented severe myositis and was refractive to corticotherapy.<\/jats:p>","DOI":"10.1177\/0961203310376637","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T20:49:02Z","timestamp":1280263742000},"page":"1659-1661","source":"Crossref","is-referenced-by-count":9,"title":["Severe and refractory myositis in mixed connective tissue disease: a description of a rare case"],"prefix":"10.1177","volume":"19","author":[{"given":"CC","family":"Bonin","sequence":"first","affiliation":[{"name":"Biomedicine, University City of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Santos Pires da Silva","sequence":"additional","affiliation":[{"name":"Biomedicine, University City of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LM","family":"Mota","sequence":"additional","affiliation":[{"name":"Rheumatology Service, Hospital Universit\u00e1rio de Bras\u00edlia, Universidade de Bras\u00edlia, Bras\u00edlia-DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JF","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,27]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu220oa"},{"key":"atypb2","author":"Hoffman RW","year":"2008","journal-title":"eMedicine"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2004000600001"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.9.1040"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.20.178"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.386"},{"key":"atypb7","first-page":"214","volume":"111","author":"Shen N.","year":"1998","journal-title":"Chin Med J"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.04.003"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.6.1182"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199606000-00014"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200411"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90258-2"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310376637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310376637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:09:53Z","timestamp":1777676993000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203310376637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,27]]},"references-count":12,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1177\/0961203310376637"],"URL":"https:\/\/doi.org\/10.1177\/0961203310376637","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,27]]}}}