{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:58:48Z","timestamp":1777928328429,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T00:00:00Z","timestamp":1291680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Antiphospholipid syndrome (APS) is a disorder of coagulation that causes thrombosis as well as pregnancy-related complications, occurring due to the autoimmune production of antibodies against phospholipid. Full anticoagulation is the cornerstone therapy in patients with thrombosis history, and this can lead to major bleeding. During a 3-year period, 300 primary and secondary APS patients were followed up at the Rheumatology Division of the authors\u2019 University Hospital. Of them, 255 (85%) were women and 180 (60%) were of reproductive age. Three of them (1%) had severe hemorrhagic corpus luteum while receiving long-term anticoagulation treatment and are described in this report. All of them were taking warfarin, had elevated international normalized ratio (&gt;4.0) and required prompt blood transfusion and emergency surgery. Therefore, we strongly recommend that all women with APS under anticoagulation should have ovulation suppressed with either intramuscular depot-medroxyprogesterone acetate or oral desogestrel.<\/jats:p>","DOI":"10.1177\/0961203310383300","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T20:49:02Z","timestamp":1291754942000},"page":"523-526","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Severe hemorrhagic corpus luteum complicating anticoagulation in antiphospholipid syndrome"],"prefix":"10.1177","volume":"20","author":[{"given":"LYS","family":"Yamakami","sequence":"first","affiliation":[{"name":"Division of Gynecology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DB","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"},{"name":"Rheumatology Department, Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CA","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"},{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EC","family":"Baracat","sequence":"additional","affiliation":[{"name":"Division of Gynecology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JF","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,12,7]]},"reference":[{"key":"bibr1-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"bibr2-0961203310383300","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-7-199304010-00005"},{"key":"bibr3-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01109-9"},{"key":"bibr4-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0674"},{"key":"bibr5-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.5.527"},{"key":"bibr6-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1177\/096120339900800614"},{"key":"bibr7-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00540.x"},{"key":"bibr8-0961203310383300","first-page":"1716","volume":"24","author":"al-Sayegh FA","year":"1997","journal-title":"J Rheumatol"},{"key":"bibr9-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1007\/s002619900502"},{"key":"bibr10-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138718"},{"key":"bibr11-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7023.83"},{"key":"bibr12-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(01)00307-9"},{"key":"bibr13-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1080\/13625180400020952"},{"key":"bibr14-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0497-z"},{"key":"bibr15-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.4.982"},{"key":"bibr16-0961203310383300","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.07.016"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310383300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203310383300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310383300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:10:07Z","timestamp":1777677007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203310383300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,7]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1177\/0961203310383300"],"URL":"https:\/\/doi.org\/10.1177\/0961203310383300","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,7]]}}}