{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:46:03Z","timestamp":1783352763187,"version":"3.54.6"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>The aim of this study was to evaluate penile anthropometry in systemic lupus erythematosus (SLE) patients compared with healthy controls and the possible relevant pubertal, clinical, hormonal and treatment factors that could influence penile dimensions. Twenty-five consecutive SLE patients were assessed by urological examination, sexual function, testicular ultrasound, hormones, sperm analysis, genetic analysis, clinical features and treatment. The control group included 25 age-matched healthy males. SLE patients had a lower median penis length and circumference [8 (7.5\u201310) vs. 10 (8\u201313) cm, p\u2009=\u20090.0001; 8 (7\u201310) vs. 10 (7\u201311) cm, p\u2009=\u20090.001; respectively], lower median testicular volume by right and left Prader [15 (10\u201325) vs. 20 (12\u201325) ml, p\u2009=\u20090.003; 15 (10\u201325) vs. 20 (12\u201325) ml, p\u2009=\u20090.006; respectively], higher median of follicle-stimulating hormone [5.8 (2.1\u201325) vs. 3.3 (1.9\u20139) IU\/l, p\u2009=\u20090.002] and lower morning total testosterone levels (28% vs. 0%, p\u2009=\u20090.009) compared with controls. In spite of that, erectile dysfunction was not observed in patients or controls. Analyses of lupus patients revealed that the median penis circumference was lower in patients with disease onset before first ejaculation compared with those with disease onset after first ejaculation [7.8 (7\u201310) vs. 9.0 (7.5\u201310) cm, p\u2009=\u20090.026]. No differences were observed in the median penile anthropometry regarding sexual dysfunction ( p\u2009=\u20090.610), lower morning total testosterone levels ( p\u2009=\u20090.662), oligo\/azoospermia ( p\u2009=\u20090.705), SLE Disease Activity Index\u2009\u2265\u20094 ( p\u2009=\u20090.562), Systemic Lupus International Collaborating Clinics\/ACR Damage Index\u2009\u2265\u20091 ( p\u2009=\u20090.478), prednisone cumulative dose ( p\u2009=\u20090.789) and intravenous cyclophosphamide therapy ( p\u2009=\u20090.754). Klinefelte\u0155s syndrome (46XY\/47XXY) was diagnosed in one (4%) SLE patient with decreased penile size whereas Y-chromosomal microdeletions was absent in all of them. In conclusion, we have identified reduced penile dimensions in SLE patients with no deleterious effect in erectile function. Disease onset before first ejaculation seems to affect penis development in pre-pubertal lupus.<\/jats:p>","DOI":"10.1177\/0961203310384121","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T21:38:50Z","timestamp":1296509930000},"page":"512-518","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Penile anthropometry in systemic lupus erythematosus patients"],"prefix":"10.1177","volume":"20","author":[{"given":"AP","family":"Vecchi","sequence":"first","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EF","family":"Borba","sequence":"additional","affiliation":[{"name":"Urology Department, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bonf\u00e1","sequence":"additional","affiliation":[{"name":"Urology Department, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cocuzza","sequence":"additional","affiliation":[{"name":"Urology Department, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pieri","sequence":"additional","affiliation":[{"name":"Pediatric Department Laboratory, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Kim","sequence":"additional","affiliation":[{"name":"Genetic Clinic Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Silva","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"},{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,31]]},"reference":[{"key":"bibr1-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1002\/art.22660"},{"key":"bibr2-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken338"},{"key":"bibr3-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1002\/art.23701"},{"key":"bibr4-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1177\/000992280104001201"},{"key":"bibr5-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1590\/S0021-75572007000600008"},{"key":"bibr6-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr7-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307077538"},{"key":"bibr8-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1159\/000052434"},{"key":"bibr9-0961203310384121","first-page":"2000","volume":"29","author":"Silva CA","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr10-0961203310384121","first-page":"16","volume":"35","author":"Araujo DB","year":"2010","journal-title":"Acta Reumatol Port"},{"key":"bibr11-0961203310384121","unstructured":"Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AM. World Health Organization (WHO) manual for the standardized investigation, diagnosis and management of the infertile male 2000 New York: Cambridge University Press; 1\u201386."},{"key":"bibr12-0961203310384121","volume-title":"Laboratory manual for the examination of human semen and sperm\u2013cervical mucus interaction","author":"World Health Organization (WHO)","year":"1999","edition":"4"},{"key":"bibr13-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.13"},{"key":"bibr14-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"bibr15-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"bibr16-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-003-0365-9"},{"key":"bibr17-0961203310384121","author":"Silva CA","year":"2010","journal-title":"Rheumatol Int"},{"key":"bibr18-0961203310384121","first-page":"207","volume":"49","author":"Silva CA","year":"2009","journal-title":"Braz J Rheumatol"},{"key":"bibr19-0961203310384121","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65682-9"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310384121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203310384121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203310384121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:10:08Z","timestamp":1777677008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203310384121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,31]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1177\/0961203310384121"],"URL":"https:\/\/doi.org\/10.1177\/0961203310384121","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,31]]}}}