{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:48:56Z","timestamp":1792604936786,"version":"4.5.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of \u22651\u2009:\u2009160, and the ratio of pleural effusion to serum ANA of \u22651, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of 54 patients with pleural effusion (12 lupus pleuritis, seven parapneumonic effusion, 26 malignancy-associated pleural effusions, nine transudative effusions) was performed. ANA at a titer of \u22651\u2009:\u2009160 were found in 11 of 12 lupus pleuritis samples, and in four of 42 pleural effusions from non-systemic lupus erythematosus (SLE) patients. The pleural effusion ANA at a titer of \u22651\u2009:\u2009160 gave a sensitivity of 91.67% for lupus pleuritis, with a specificity of 83.33% when compared with all other pleural effusions, 90.91% when compared with exudative effusion (parapneumonic effusion and malignancy-associated effusion) and 55.56% when compared with the transudative pleural effusion group. Using the ratio of pleural effusion to serum ANA of \u22651, the sensitivity and the specificity decreased to 75.00% and 78.57%, respectively. This study provides further evidence that the pleural effusion ANA at a titer of \u22651\u2009:\u2009160 is a sensitive and specific diagnostic biomarker for lupus pleuritis in patients with lupus. However, pleural effusion ANA can occasionally be found in other conditions.<\/jats:p>","DOI":"10.1177\/0961203311402531","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T04:47:38Z","timestamp":1307681258000},"page":"1042-1046","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Usefulness of pleural effusion antinuclear antibodies in the diagnosis of lupus pleuritis"],"prefix":"10.1177","volume":"20","author":[{"given":"C","family":"Toworakul","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kasitanon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Sukitawut","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wichinun","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Louthrenoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"bibr1-0961203311402531","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070150014003"},{"key":"bibr2-0961203311402531","first-page":"85","volume":"20","author":"Kasitanon N","year":"2002","journal-title":"Asian Pac J Allergy Immunol"},{"key":"bibr3-0961203311402531","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.3.866"},{"key":"bibr4-0961203311402531","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306074470"},{"key":"bibr5-0961203311402531","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.6.714"},{"key":"bibr6-0961203311402531","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr7-0961203311402531","unstructured":"Light RW. 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