{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:09:54Z","timestamp":1789819794459,"version":"4.0.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Mycophenolic acid, in combination with glucocorticoids, has been shown in a series of trials to be safe and effective for treatment of lupus nephritis. Regimens that permit glucocorticoid dose reduction without loss of efficacy would be advantageous. MyLupus was a 24-week, multicentre, open-label, study in patients with active proliferative lupus nephritis treated with enteric-coated mycophenolate sodium (EC-MPS), randomized to standard-dose ( n\u2009=\u200942) or reduced-dose ( n\u2009=\u200939) glucocorticoids. Complete response at week 24, the primary endpoint, was achieved in 19.8% (16\/81) of patients (19.0% standard-dose, 20.5% reduced-dose; lower limit of 97.5% CI for the difference \u221215.9%, p\u2009=\u20090.098, i.e. non-inferiority was not shown). Partial response occurred in 42.0% of patients (34\/81). From baseline to week 24, the mean global British Isles Lupus Assessment Group (BILAG) score decreased from 14.0\u2009\u00b1\u20095.4 to 5.0\u2009\u00b1\u20093.8 ( p\u2009&lt;\u20090.001). The incidence of adverse events was 80.2% (65\/81), most frequently gastrointestinal complications (31\/81, 38.3%). Infections were reported in 57.1% and 35.9% of standard- and reduced-dose glucocorticoid patients, respectively ( p\u2009=\u20090.056), with herpes zoster in 16.7% and 0% ( p\u2009=\u20090.012). Three patients discontinued study medication due to adverse events. This exploratory study suggests that EC-MPS may facilitate glucocorticoid reduction without loss of efficacy in patients with active lupus nephritis, but results require confirmation in a controlled, longer-term study versus the current standard of care.<\/jats:p>","DOI":"10.1177\/0961203311418269","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T02:09:33Z","timestamp":1317866973000},"page":"1484-1493","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":134,"title":["Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis"],"prefix":"10.1177","volume":"20","author":[{"given":"M","family":"Zeher","sequence":"first","affiliation":[{"name":"Institute for Internal Medicine, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Doria","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lan","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Aroca","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de la Costa, Barranquilla, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Jayne","sequence":"additional","affiliation":[{"name":"Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Boletis","sequence":"additional","affiliation":[{"name":"Laiko Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Hiepe","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Prestele","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Amoura","sequence":"additional","affiliation":[{"name":"Pitie-Salpetriere Hospital, French National Reference Centre for SLE, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,10,5]]},"reference":[{"key":"bibr1-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu158oa"},{"key":"bibr2-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0905-8"},{"key":"bibr3-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1007\/BF00865490"},{"key":"bibr4-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181907b3d"},{"key":"bibr5-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.11.034"},{"key":"bibr6-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90029-9"},{"key":"bibr7-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106892"},{"key":"bibr8-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031855"},{"key":"bibr9-0961203311418269","first-page":"276","volume":"22","author":"Boumpas DT","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"bibr10-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1002\/art.20599"},{"key":"bibr11-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308090991"},{"key":"bibr12-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008101028"},{"key":"bibr13-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043731"},{"key":"bibr14-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004080686"},{"key":"bibr15-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.412"},{"key":"bibr16-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm066"},{"key":"bibr17-0961203311418269","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01200307"},{"key":"bibr18-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309357763"},{"key":"bibr19-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1002\/art.25052"},{"key":"bibr20-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.131995"},{"key":"bibr21-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2004.00318.x"},{"key":"bibr22-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251969.72691.ea"},{"key":"bibr23-0961203311418269","doi-asserted-by":"publisher","DOI":"10.5414\/CNP69090"},{"key":"bibr24-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00862.x"},{"key":"bibr25-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr26-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"bibr27-0961203311418269","first-page":"447","volume":"86","author":"Hay EM","year":"1993","journal-title":"Q J Med"},{"key":"bibr28-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.10.756"},{"key":"bibr29-0961203311418269","first-page":"1934","volume":"31","author":"Uribe AG","year":"2004","journal-title":"J Rheumatol"},{"key":"bibr30-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"bibr31-0961203311418269","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01140.x"},{"key":"bibr32-0961203311418269","first-page":"2390","volume":"31","author":"Wollaston SJ","year":"2004","journal-title":"J Rheumatology"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203311418269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203311418269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203311418269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:10:59Z","timestamp":1777677059000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203311418269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,5]]},"references-count":32,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1177\/0961203311418269"],"URL":"https:\/\/doi.org\/10.1177\/0961203311418269","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,5]]}}}