{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:59:24Z","timestamp":1777928364002,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>African-American recipients of kidney transplants with lupus have high allograft failure risk. We studied their risk adjusting for: (1) socio-demographic factors: donor age, gender and race-ethnicity; recipient age, gender, education and insurance; donor\u2013recipient race-ethnicity match; (2) immunologic factors: donor type, panel reactive antibodies, HLA mismatch, ABO blood type compatibility, pre-transplant dialysis, cytomegalovirus risk and delayed graft function (DGF); (3) rejection and recurrent lupus nephritis (RLN). Two thousand four hundred and six African-, 1132 Hispanic-, and 2878 Caucasian-Americans were followed for 12 years after transplantation. African- versus Hispanic- and Caucasian-Americans received more kidneys from deceased donors (71.6%, 57.3% and 55.1%) with higher two HLA loci mismatches for HLA-A (50%, 39.6% and 32.4%), HLA-B (52%, 42.8% and 35.6%) and HLA-DR (30%, 24.5% and 21.1%). They developed more DGF (19.5%, 13.6% and 13.4%). More African- versus Hispanic- and Caucasian-Americans developed rejection (41.7%, 27.6% and 35.9%) and RLN (3.2, 1.8 and 1.8%). 852 African-, 265 Hispanic-, and 747 Caucasian-Americans had allograft failure ( p\u2009&lt;\u20090.0001). After adjusting for transplant era, socio-demographic-immunologic differences, rejection and RLN, the increased hazard ratio for allograft failure of African- compared with Caucasian-Americans became non-significant (1.26 [95% confidence interval 0.78\u20132.04]). African-Americans with lupus have high prevalence of risk factors for allograft failure that can explain poor outcomes.<\/jats:p>","DOI":"10.1177\/0961203311421208","type":"journal-article","created":{"date-parts":[[2011,10,6]],"date-time":"2011-10-06T02:09:33Z","timestamp":1317866973000},"page":"3-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Kidney transplantation outcomes in African-, Hispanic- and Caucasian-Americans with lupus"],"prefix":"10.1177","volume":"21","author":[{"given":"G","family":"Contreras","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, Miami, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mattiazzi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, Miami, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DR","family":"Schultz","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, University of Miami, Miller School of Medicine, Miami, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Guerra","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, Miami, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ladino","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, Miami, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LM","family":"Ortega","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, Miami, 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