{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:17:02Z","timestamp":1782775022523,"version":"3.54.5"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Purpose: To evaluate sexual function of antiphospholipid syndrome (APS) patients using the Brazilian version of the validated International Index of Erectile Function (IIEF).<\/jats:p>\n                  <jats:p>Materials and methods: Eleven APS male patients (Sapporo criteria) were age and race-matched with 22 healthy controls. Demographic and clinical data, drug use and antiphospholipid antibodies were evaluated. The IIEF was also self-applied.<\/jats:p>\n                  <jats:p>Results: Mean age ( p\u2009=\u20090.114), frequency of Caucasian race ( p\u2009=\u20091.00) and married status ( p\u2009=\u20090.438) were similar in APS and controls. Mean disease duration was 8.8\u2009\u00b1\u20094.6 years. Erectile dysfunction (ED) was frequently observed in APS versus controls (45.5 vs. 4.5%, p\u2009=\u20090.0096), especially moderate\/severe ED ( p\u2009=\u20090.0081). The total IIEF score (49.6 vs. 67.1, p\u2009=\u20090.019), erectile function (19.6 vs. 28.1, p\u2009=\u20090.005) and intercourse satisfaction (7.8 vs. 11.9, p\u2009=\u20090.009) were lower in patients than in controls. No differences were seen in orgasmic function ( p\u2009=\u20090.114), sexual desire ( p\u2009=\u20090.123) or overall satisfaction ( p\u2009=\u20090.097) between the groups. The comparison between APS patients with ED ( n\u2009=\u20095) and without ED ( n\u2009=\u20096) revealed more arterial events in APS with ED (100 vs. 16.7%, p\u2009=\u20090.0152), and also longer disease duration (12 [7\u201316] vs. 5.5 [2\u201313] years, p\u2009=\u20090.031). A trend towards lower venous events (20 vs. 83.3%, p\u2009=\u20090.0801) and higher renal thrombotic microangiopathy (60% vs. 0, p\u2009=\u20090.0606) was observed in APS patients with ED. Demographics, clinical manifestations, smoking and antiphospholipid antibodies positivity were similar in both groups.<\/jats:p>\n                  <jats:p>Conclusion: To our knowledge, this was the first study that demonstrated moderate\/severe ED in almost 50% of cases of a rare autoimmune disease. This alteration was linked to arterial events and longer disease duration.<\/jats:p>","DOI":"10.1177\/0961203311427552","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T00:24:24Z","timestamp":1320971064000},"page":"319-323","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Moderate\/severe erectile dysfunction in patients with antiphospholipid syndrome"],"prefix":"10.1177","volume":"21","author":[{"given":"A","family":"Lopes Gallinaro","sequence":"first","affiliation":[{"name":"Rheumatology Division, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Silva","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CN","family":"Rabelo Junior","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MT","family":"Correia Caleiro","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JF","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"bibr1-0961203311427552","first-page":"16","volume":"35","author":"Araujo DB","year":"2010","journal-title":"Acta Reumatol Port"},{"key":"bibr2-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<440::AID-ANR26>3.0.CO;2-N"},{"key":"bibr3-0961203311427552","first-page":"35","volume":"55","author":"Ferraz MB","year":"1998","journal-title":"Rev Bras Med"},{"key":"bibr4-0961203311427552","doi-asserted-by":"publisher","DOI":"10.4103\/0973-3930.57345"},{"key":"bibr5-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1177\/000331970605700107"},{"key":"bibr6-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.09.035"},{"key":"bibr7-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02015.x"},{"key":"bibr8-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310384121"},{"key":"bibr9-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1080\/00926230903375719"},{"key":"bibr10-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000117867.44858.ba"},{"key":"bibr11-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302008000900006"},{"key":"bibr12-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2009.44"},{"key":"bibr13-0961203311427552","first-page":"1074","volume":"32","author":"Le Pioufle N","year":"2003","journal-title":"Presse Med"},{"key":"bibr14-0961203311427552","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.089"},{"key":"bibr15-0961203311427552","first-page":"677","volume":"49","author":"Silva CAA","year":"2009","journal-title":"Braz J Rheumatol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203311427552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203311427552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203311427552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:11:14Z","timestamp":1777677074000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203311427552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,10]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1177\/0961203311427552"],"URL":"https:\/\/doi.org\/10.1177\/0961203311427552","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,10]]}}}