{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:59:34Z","timestamp":1777928374992,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>The tuberculin skin test (TST) has low sensitivity for the diagnosis of tuberculosis (TB). QuantiFERON-TB Gold (QFT-G) is an IFN-gamma-release assay that measures the release of interferon-gamma after stimulation in\u00a0vitro by Mycobacterium tuberculosis antigens using ELISA. The main advantage of this assay compared with TST is the lack of cross-reaction with Bacillus Calmette-Gu\u00e9rin (BCG) as well as most of non-tuberculous mycobacteria. The aim of our study is to compare QFT-G with TST for the detection of latent tuberculosis infection (LTBI) among patients with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <jats:p>Methods: Seventy-eight patients with SLE and 49 healthy subjects (HCs) participated in the study. All patients and controls were interviewed for a history of TB then BCG vaccinations were recorded and chest X-rays were examined for a sign of TB infection. QTF-G and TST were performed on both patients and controls. QTF-G results were recorded as positive, negative or indeterminate. A positive TST for SLE was defined as \u22655\u2009mm.<\/jats:p>\n                  <jats:p>Results: Seventy-six SLE patients (97.4%) had been BCG vaccinated. Similar to the HC (28.5%), 19 of 78 (24.3%) SLE patients had positive QTF-G. Two patients had an indeterminate result. The agreement between QTF-G and TST was 49\/76 (64.4%) (\u03ba\u2009=\u20090.33). There were fewer positive QFT-G test results than positive TST results (24.3% vs. 50%; p\u2009&lt;\u20090.01). Twenty-two (28.9%) patients were TST(+)\/QTF-G(\u2212) while only 3(3.9%) patients were TST(\u2212)\/QTF-G(+). When the positive TST was defined as \u226510\u2009mm indurations, which is the cut-off in screening for LTBI in Turkey, the agreement between two tests increased up to 58\/76 (76.3%) with a \u03ba value of 0.47. The mean TST measurements was higher in QTF-G positive patients (13.4\u2009\u00b1\u20098.8\u2009mm) than the QTF-G negative patients (4\u2009\u00b1\u20095.3\u2009mm) ( p\u2009&lt;\u20090.001).<\/jats:p>\n                  <jats:p>Discussion: In a TB-endemic and BCG vaccinated population, the QuantiFERON-TB Gold assay seemed to be a more accurate test for the detection of LTBI in SLE patients. Although 5\u2009mm is usually accepted to be the standard cut-off for TST in immunocompromised patients such as SLE, the level of agreement between QTF-G and TST was better with a 10\u2009mm cut-off in our population.<\/jats:p>","DOI":"10.1177\/0961203311430700","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T15:24:24Z","timestamp":1322925864000},"page":"491-495","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of QuantiFERON-TB Gold test and tuberculin skin test for the identification of latent\n                    <i>Mycobacterium tuberculosis<\/i>\n                    infection in lupus patients"],"prefix":"10.1177","volume":"21","author":[{"given":"N","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Rheumatology, Marmara University Faculty of Medicine, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Zehra Aydin","sequence":"additional","affiliation":[{"name":"Rheumatology, Marmara University Faculty of Medicine, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Inanc","sequence":"additional","affiliation":[{"name":"Rheumatology, Marmara University Faculty of Medicine, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Karakurt","sequence":"additional","affiliation":[{"name":"Chest Medicine, Marmara University Faculty of Medicine, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Direskeneli","sequence":"additional","affiliation":[{"name":"Rheumatology, Marmara University Faculty of Medicine, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Rheumatology, Marmara University Faculty of Medicine, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,2]]},"reference":[{"key":"bibr1-0961203311430700","unstructured":"Gumuslu F, Ankara S, Ozkan S, The 2007 Turk\u0131sh report of tuberculosis. 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