{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:37Z","timestamp":1789609117991,"version":"build-2803163510"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>While mainly based on the use of fluorinated steroids, there is no standard management of anti-Ro\/La-related congenital heart block (CHB). This is a report concerning two consecutive cases of anti-Ro\/La-related second-degree block treated with betamethasone (4\u2009mg\/day), weekly plasmapheresis, and intravenous immunoglobulins (IVIGs; 1\u2009g\/kg) administered every 15 days, a therapy that was begun shortly after CHB was detected and continued until delivery. The newborns were also treated with IVIG (1\u2009g\/kg) soon after birth and continued fortnightly until the anti-Ro\/La antibody levels became undetectable. In both cases second-degree AV block reverted to a stable sinus rhythm with a first-degree atrioventricular (AV) block. Moreover, there was no recurrence of CHB when therapy was suspended, as confirmed by a 29 month and an eight month follow-up, respectively.<\/jats:p>","DOI":"10.1177\/0961203311430969","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T23:42:01Z","timestamp":1324424521000},"page":"666-671","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["A combination therapy to treat second-degree anti-Ro\/La-related congenital heart block. A strategy to avoid stable third-degree heart block?"],"prefix":"10.1177","volume":"21","author":[{"given":"A","family":"Ruffatti","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy; 2Department of Paediatrics, University of Padua, Padua, Italy; 3Obstetrics and Gynaecology Unit, Hospital of Padua, Padua, Italy; 4Blood Transfusion Unit, Hospital of Padua, Padua, Italy; and 5Cardiology Unit, Department of Cardio-thoracic and Vascular Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Milanesi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy; 2Department of Paediatrics, University of Padua, Padua, Italy; 3Obstetrics and Gynaecology Unit, Hospital of Padua, Padua, Italy; 4Blood Transfusion Unit, Hospital of Padua, Padua, Italy; and 5Cardiology Unit, Department of Cardio-thoracic and Vascular Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chiandetti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy; 2Department of Paediatrics, University of Padua, Padua, Italy; 3Obstetrics and Gynaecology Unit, Hospital of Padua, Padua, Italy; 4Blood Transfusion Unit, Hospital of Padua, Padua, Italy; and 5Cardiology Unit, Department of Cardio-thoracic and Vascular Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cerutti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy; 2Department of Paediatrics, University of Padua, Padua, Italy; 3Obstetrics and Gynaecology Unit, Hospital of Padua, Padua, Italy; 4Blood Transfusion Unit, Hospital of Padua, Padua, Italy; and 5Cardiology Unit, Department of Cardio-thoracic and Vascular Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MT","family":"Gervasi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy; 2Department of Paediatrics, University of Padua, Padua, Italy; 3Obstetrics and Gynaecology Unit, Hospital of Padua, Padua, Italy; 4Blood Transfusion Unit, Hospital of Padua, Padua, Italy; and 5Cardiology Unit, Department of Cardio-thoracic and Vascular Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"De Silvestro","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy; 2Department of Paediatrics, University of Padua, Padua, Italy; 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