{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:30Z","timestamp":1791352290462,"version":"4.3.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T00:00:00Z","timestamp":1329177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Statin use has been advocated to prevent atheromatous complications in lupus patients and may be widely prescribed for these patients in future. Statin-induced lupus has also been described, though the risk is not confirmed. The goal of this study was to detect a safety signal regarding statin-induced lupus. We conducted a case\/non-case study in the French PharmacoVigilance Database from January 2000 until December 2010. Cases were drug-induced lupus reports. Non-cases were all reports of other adverse drug reactions (ADRs). Exposure to statins at the time of ADR was screened in each report. Among 235,147 ADR reports, 232 were drug-induced lupus. Exposure to statins was present in 17 (7.3%) cases and in 10,601 (4.7%) non-cases. Reporting odds ratio (ROR) for statin exposure associated with lupus erythematosus was 1.67 (95% confidence interval 1.02\u20132.74). The ROR was\u2009&gt;\u20091 for each statin but fluvastatin. This pharmacoepidemiological study suggests a link between statin exposure and lupus induction. The benefit-to-risk ratio of statin therapy in lupus patients should be evaluated through randomized controlled trials.<\/jats:p>","DOI":"10.1177\/0961203312436861","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T22:58:59Z","timestamp":1329260339000},"page":"885-889","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Statin-induced lupus: a case\/non-case study in a nationwide pharmacovigilance database"],"prefix":"10.1177","volume":"21","author":[{"given":"G","family":"Moulis","sequence":"first","affiliation":[{"name":"CHU Toulouse, Service de M\u00e9decine Interne, Toulouse, F-31059, France"},{"name":"CHU Toulouse, Service de Pharmacologie Clinique, Centre Midi-Pyr\u00e9n\u00e9es de PharmacoVigilance, de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament, Toulouse, F-31059, France"},{"name":"Inserm, UMR1027, Toulouse, F-31073, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, F-31073, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"B\u00e9n\u00e9","sequence":"additional","affiliation":[{"name":"CHU Lille, Centre Nord-Pas de Calais de PharmacoVigilance, Lille, F-59037, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sommet","sequence":"additional","affiliation":[{"name":"CHU Toulouse, Service de Pharmacologie Clinique, Centre Midi-Pyr\u00e9n\u00e9es de PharmacoVigilance, de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament, Toulouse, F-31059, France"},{"name":"Inserm, UMR1027, Toulouse, F-31073, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, F-31073, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Sailler","sequence":"additional","affiliation":[{"name":"CHU Toulouse, Service de M\u00e9decine Interne, Toulouse, F-31059, France"},{"name":"CHU Toulouse, Service de Pharmacologie Clinique, Centre Midi-Pyr\u00e9n\u00e9es de PharmacoVigilance, de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament, Toulouse, F-31059, France"},{"name":"Inserm, UMR1027, Toulouse, F-31073, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, F-31073, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lapeyre-Mestre","sequence":"additional","affiliation":[{"name":"CHU Toulouse, Service de Pharmacologie Clinique, Centre Midi-Pyr\u00e9n\u00e9es de PharmacoVigilance, de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament, Toulouse, F-31059, France"},{"name":"Inserm, UMR1027, Toulouse, F-31073, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, F-31073, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L","family":"Montastruc","sequence":"additional","affiliation":[{"name":"CHU Toulouse, Service de Pharmacologie Clinique, Centre Midi-Pyr\u00e9n\u00e9es de PharmacoVigilance, de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament, Toulouse, F-31059, France"},{"name":"Inserm, UMR1027, Toulouse, F-31073, France"},{"name":"Universit\u00e9 de Toulouse III, UMR1027, Toulouse, F-31073, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The French Association of PharmacoVigilance Centres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,2,14]]},"reference":[{"key":"bibr1-0961203312436861","first-page":"RA245","volume":"16","author":"Chalubinski M","year":"2010","journal-title":"Med Sci 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http:\/\/www.whocc.no\/atc_ddd_index (2011, accessed 1 August 2011)."},{"key":"bibr11-0961203312436861","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04037.x"},{"key":"bibr12-0961203312436861","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10397.x"},{"key":"bibr13-0961203312436861","doi-asserted-by":"crossref","unstructured":"De Jong HJ, Cohen Tervaert JW, Saldi SR,\n                      et al\n                      . Association between statin use and lupus-like syndrome using spontaneous reports.\n                      Semin Arthritis Rheum\n                      2011; 41: 373\u2013381.","DOI":"10.1016\/j.semarthrit.2011.06.002"},{"key":"bibr14-0961203312436861","doi-asserted-by":"publisher","DOI":"10.1177\/009286150804200501"},{"key":"bibr15-0961203312436861","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075523"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312436861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203312436861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312436861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:11:53Z","timestamp":1777677113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203312436861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,14]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1177\/0961203312436861"],"URL":"https:\/\/doi.org\/10.1177\/0961203312436861","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,14]]}}}