{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:29:31Z","timestamp":1790857771587,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T00:00:00Z","timestamp":1332720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Objective: To evaluate clinicopathological features and treatment response in patients with lupus nephritis (LN), comparing the childhood- and late-onset forms of the disease. Methods: We retrospectively analyzed clinical presentation, treatment and evolution in patients diagnosed with LN by renal biopsy between 1999 and 2008. Patients were grouped by age\u2014\u226418 years ( n\u2009=\u200923); and \u226550 years ( n\u2009=\u200913)\u2014and were followed for the first year of treatment. Results: The baseline features of the childhood- and late-onset groups, respectively, were as follows: mean age, 15\u2009\u00b1\u20092 and 54\u2009\u00b1\u20095 years; female gender, 87% and 92%; hypertension, 87% and 77%; Systemic Lupus Erythematosus Disease Activity Index, 29\u2009\u00b1\u20099 and 17\u2009\u00b1\u20097 ( p\u2009=\u20090.002); estimated glomerular filtration rate (eGFR), 86\u2009\u00b1\u200966 and 70\u2009\u00b1\u200918\u2009ml\/min; concurrent SLE\/LN diagnosis, 90% and 15% ( p\u2009&lt;\u20090.001); crescents on biopsy, 74% and 30% ( p\u2009=\u20090.02); activity index on biopsy, 4.8\u2009\u00b1\u20092.6 and 3.3\u2009\u00b1\u20091.9 ( p\u2009=\u20090.10); and interstitial fibrosis (&gt;10%), 39% and 61% ( p\u2009=\u20090.08). Treatment consisted mainly of methylprednisolone, prednisone and intravenous cyclophosphamide, average cumulative doses being similar between the groups. After 12 months of treatment, the eGFR in the younger and older patients was 116\u2009\u00b1\u200962 and 78\u2009\u00b1\u200920\u2009ml\/min, respectively ( p\u2009=\u20090.005). Three of the younger patients progressed to dialysis at 12 months, compared with none of the older patients. Conclusion: Childhood-onset LN seems to be more severe than is late-onset LN.<\/jats:p>","DOI":"10.1177\/0961203312443421","type":"journal-article","created":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T22:49:48Z","timestamp":1332802188000},"page":"978-983","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["Lupus nephritis is more severe in children and adolescents than in older adults"],"prefix":"10.1177","volume":"21","author":[{"given":"VAH","family":"Sato","sequence":"first","affiliation":[{"name":"Nephrology Division, University of S\u00e3o Paulo, School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IDB","family":"Marques","sequence":"additional","affiliation":[{"name":"Nephrology Division, University of S\u00e3o Paulo, School of Medicine, S\u00e3o Paulo, 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